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What are the key conditions associated with lower limb amputations in a major Australian teaching hospital?

BACKGROUND: Lower extremity amputation results in significant global morbidity and mortality. Australia appears to have a paucity of studies investigating lower extremity amputation. The primary aim of this retrospective study was to investigate key conditions associated with lower extremity amputat...

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Autores principales: Lazzarini, Peter A, O’Rourke, Sharon R, Russell, Anthony W, Clark, Damien, Kuys, Suzanne S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464163/
https://www.ncbi.nlm.nih.gov/pubmed/22647678
http://dx.doi.org/10.1186/1757-1146-5-12
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author Lazzarini, Peter A
O’Rourke, Sharon R
Russell, Anthony W
Clark, Damien
Kuys, Suzanne S
author_facet Lazzarini, Peter A
O’Rourke, Sharon R
Russell, Anthony W
Clark, Damien
Kuys, Suzanne S
author_sort Lazzarini, Peter A
collection PubMed
description BACKGROUND: Lower extremity amputation results in significant global morbidity and mortality. Australia appears to have a paucity of studies investigating lower extremity amputation. The primary aim of this retrospective study was to investigate key conditions associated with lower extremity amputations in an Australian population. Secondary objectives were to determine the influence of age and sex on lower extremity amputations, and the reliability of hospital coded amputations. METHODS: Lower extremity amputation cases performed at the Princess Alexandra Hospital (Brisbane, Australia) between July 2006 and June 2007 were identified through the relevant hospital discharge dataset (n = 197). All eligible clinical records were interrogated for age, sex, key condition associated with amputation, amputation site, first ever amputation status and the accuracy of the original hospital coding. Exclusion criteria included records unavailable for audit and cases where the key condition was unable to be determined. Chi-squared, t-tests, ANOVA and post hoc tests were used to determine differences between groups. Kappa statistics were used to measure reliability between coded and audited amputations. A minimum significance level of p < 0.05 was used throughout. RESULTS: One hundred and eighty-six cases were eligible and audited. Overall 69% were male, 56% were first amputations, 54% were major amputations, and mean age was 62 ± 16 years. Key conditions associated included type 2 diabetes (53%), peripheral arterial disease (non-diabetes) (18%), trauma (8%), type 1 diabetes (7%) and malignant tumours (5%). Differences in ages at amputation were associated with trauma 36 ± 10 years, type 1 diabetes 52 ± 12 years and type 2 diabetes 67 ± 10 years (p < 0.01). Reliability of original hospital coding was high with Kappa values over 0.8 for all variables. CONCLUSIONS: This study, the first in over 20 years to report on all levels of lower extremity amputations in Australia, found that people undergoing amputation are more likely to be older, male and have diabetes. It is recommended that large prospective studies are implemented and national lower extremity amputation rates are established to address the large preventable burden of lower extremity amputation in Australia.
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spelling pubmed-34641632012-10-05 What are the key conditions associated with lower limb amputations in a major Australian teaching hospital? Lazzarini, Peter A O’Rourke, Sharon R Russell, Anthony W Clark, Damien Kuys, Suzanne S J Foot Ankle Res Research BACKGROUND: Lower extremity amputation results in significant global morbidity and mortality. Australia appears to have a paucity of studies investigating lower extremity amputation. The primary aim of this retrospective study was to investigate key conditions associated with lower extremity amputations in an Australian population. Secondary objectives were to determine the influence of age and sex on lower extremity amputations, and the reliability of hospital coded amputations. METHODS: Lower extremity amputation cases performed at the Princess Alexandra Hospital (Brisbane, Australia) between July 2006 and June 2007 were identified through the relevant hospital discharge dataset (n = 197). All eligible clinical records were interrogated for age, sex, key condition associated with amputation, amputation site, first ever amputation status and the accuracy of the original hospital coding. Exclusion criteria included records unavailable for audit and cases where the key condition was unable to be determined. Chi-squared, t-tests, ANOVA and post hoc tests were used to determine differences between groups. Kappa statistics were used to measure reliability between coded and audited amputations. A minimum significance level of p < 0.05 was used throughout. RESULTS: One hundred and eighty-six cases were eligible and audited. Overall 69% were male, 56% were first amputations, 54% were major amputations, and mean age was 62 ± 16 years. Key conditions associated included type 2 diabetes (53%), peripheral arterial disease (non-diabetes) (18%), trauma (8%), type 1 diabetes (7%) and malignant tumours (5%). Differences in ages at amputation were associated with trauma 36 ± 10 years, type 1 diabetes 52 ± 12 years and type 2 diabetes 67 ± 10 years (p < 0.01). Reliability of original hospital coding was high with Kappa values over 0.8 for all variables. CONCLUSIONS: This study, the first in over 20 years to report on all levels of lower extremity amputations in Australia, found that people undergoing amputation are more likely to be older, male and have diabetes. It is recommended that large prospective studies are implemented and national lower extremity amputation rates are established to address the large preventable burden of lower extremity amputation in Australia. BioMed Central 2012-05-30 /pmc/articles/PMC3464163/ /pubmed/22647678 http://dx.doi.org/10.1186/1757-1146-5-12 Text en Copyright ©2012 Lazzarini et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research
Lazzarini, Peter A
O’Rourke, Sharon R
Russell, Anthony W
Clark, Damien
Kuys, Suzanne S
What are the key conditions associated with lower limb amputations in a major Australian teaching hospital?
title What are the key conditions associated with lower limb amputations in a major Australian teaching hospital?
title_full What are the key conditions associated with lower limb amputations in a major Australian teaching hospital?
title_fullStr What are the key conditions associated with lower limb amputations in a major Australian teaching hospital?
title_full_unstemmed What are the key conditions associated with lower limb amputations in a major Australian teaching hospital?
title_short What are the key conditions associated with lower limb amputations in a major Australian teaching hospital?
title_sort what are the key conditions associated with lower limb amputations in a major australian teaching hospital?
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464163/
https://www.ncbi.nlm.nih.gov/pubmed/22647678
http://dx.doi.org/10.1186/1757-1146-5-12
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