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ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature

A 23-year-old male presented with pulmonary tuberculosis and swelling of both lower limbs. He was put on antitubercular treatment. Hemogram showed mild anemia and Pseudo Pelger-huet cells. The bone marrow (BM) examination showed 52% promyelocytes with regular round to oval nuclei, few granules and w...

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Autores principales: Palta, Anshu, Dhiman, Pratibha, Cruz, Sanjay D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464342/
https://www.ncbi.nlm.nih.gov/pubmed/23071480
http://dx.doi.org/10.5045/kjh.2012.47.3.229
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author Palta, Anshu
Dhiman, Pratibha
Cruz, Sanjay D.
author_facet Palta, Anshu
Dhiman, Pratibha
Cruz, Sanjay D.
author_sort Palta, Anshu
collection PubMed
description A 23-year-old male presented with pulmonary tuberculosis and swelling of both lower limbs. He was put on antitubercular treatment. Hemogram showed mild anemia and Pseudo Pelger-huet cells. The bone marrow (BM) examination showed 52% promyelocytes with regular round to oval nuclei, few granules and were positive for CD13 and CD33, and negative for HLA-DR. Cytogenetic analysis of the BM aspirate revealed an apparently balanced t(11;17)(q23;q21). Final diagnosis rendered was acute promyelocytic leukemia (APL) with t(11;17)(q23;q21); ZBTB16/RARA. APL is a distinct subtype of acute myeloid leukemia. The variant APL with t(11;17)(q23;q21) cases that are associated with the ZBTB16/RARA fusion gene have been reported as being resistant to all-trans-retinoic acid (ATRA). Therefore, differential diagnosis of variant APL with t(11;17)(q23;q12) from classical APL with t(15;17)(q22;q12); PML-RARA is very important. Here we have discussed the importance of distinct morphology of variant APL and also significance of rare presentation with tuberculosis.
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spelling pubmed-34643422012-10-15 ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature Palta, Anshu Dhiman, Pratibha Cruz, Sanjay D. Korean J Hematol Case Report A 23-year-old male presented with pulmonary tuberculosis and swelling of both lower limbs. He was put on antitubercular treatment. Hemogram showed mild anemia and Pseudo Pelger-huet cells. The bone marrow (BM) examination showed 52% promyelocytes with regular round to oval nuclei, few granules and were positive for CD13 and CD33, and negative for HLA-DR. Cytogenetic analysis of the BM aspirate revealed an apparently balanced t(11;17)(q23;q21). Final diagnosis rendered was acute promyelocytic leukemia (APL) with t(11;17)(q23;q21); ZBTB16/RARA. APL is a distinct subtype of acute myeloid leukemia. The variant APL with t(11;17)(q23;q21) cases that are associated with the ZBTB16/RARA fusion gene have been reported as being resistant to all-trans-retinoic acid (ATRA). Therefore, differential diagnosis of variant APL with t(11;17)(q23;q12) from classical APL with t(15;17)(q22;q12); PML-RARA is very important. Here we have discussed the importance of distinct morphology of variant APL and also significance of rare presentation with tuberculosis. Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis 2012-09 2012-09-25 /pmc/articles/PMC3464342/ /pubmed/23071480 http://dx.doi.org/10.5045/kjh.2012.47.3.229 Text en © 2012 Korean Society of Hematology http://creativecommons.org/licenses/by-nc/3.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Palta, Anshu
Dhiman, Pratibha
Cruz, Sanjay D.
ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature
title ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature
title_full ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature
title_fullStr ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature
title_full_unstemmed ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature
title_short ZBTB16-RARα variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature
title_sort zbtb16-rarα variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464342/
https://www.ncbi.nlm.nih.gov/pubmed/23071480
http://dx.doi.org/10.5045/kjh.2012.47.3.229
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