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Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours

PURPOSE: Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF wit...

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Autores principales: Grüner, Julie Marie, Paamand, Rune, Kosteljanetz, Michael, Broholm, Helle, Højgaard, Liselotte, Law, Ian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer-Verlag 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464373/
https://www.ncbi.nlm.nih.gov/pubmed/22736199
http://dx.doi.org/10.1007/s00259-012-2173-1
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author Grüner, Julie Marie
Paamand, Rune
Kosteljanetz, Michael
Broholm, Helle
Højgaard, Liselotte
Law, Ian
author_facet Grüner, Julie Marie
Paamand, Rune
Kosteljanetz, Michael
Broholm, Helle
Højgaard, Liselotte
Law, Ian
author_sort Grüner, Julie Marie
collection PubMed
description PURPOSE: Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with (15)O-labelled water ((15)O-H(2)O). METHODS: On the same day within a few hours, rCBF was measured in ten adult patients with treatment-naïve primary brain tumours, twice using (15)O-H(2)O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared. RESULTS: PCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2 ± 18.8 ml min(−1) 100 ml(−1) for PET and 78.9 ± 41.8 ml min(−1) 100 ml(−1) for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9 ± 15.8 ml min(−1) 100 ml(−1) for low-grade (WHO I + II) and 81.5 ± 15.4 ml min(−1) 100 ml(−1) for high-grade (WHO III + IV) tumours, but not for PET. The rCBF PCT and PET correlation was only significant within tumours in two patients. CONCLUSION: Although intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and (15)O-H(2)O PET in brain tumours.
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spelling pubmed-34643732012-10-05 Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours Grüner, Julie Marie Paamand, Rune Kosteljanetz, Michael Broholm, Helle Højgaard, Liselotte Law, Ian Eur J Nucl Med Mol Imaging Original Article PURPOSE: Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with (15)O-labelled water ((15)O-H(2)O). METHODS: On the same day within a few hours, rCBF was measured in ten adult patients with treatment-naïve primary brain tumours, twice using (15)O-H(2)O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared. RESULTS: PCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2 ± 18.8 ml min(−1) 100 ml(−1) for PET and 78.9 ± 41.8 ml min(−1) 100 ml(−1) for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9 ± 15.8 ml min(−1) 100 ml(−1) for low-grade (WHO I + II) and 81.5 ± 15.4 ml min(−1) 100 ml(−1) for high-grade (WHO III + IV) tumours, but not for PET. The rCBF PCT and PET correlation was only significant within tumours in two patients. CONCLUSION: Although intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and (15)O-H(2)O PET in brain tumours. Springer-Verlag 2012-06-27 2012 /pmc/articles/PMC3464373/ /pubmed/22736199 http://dx.doi.org/10.1007/s00259-012-2173-1 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited.
spellingShingle Original Article
Grüner, Julie Marie
Paamand, Rune
Kosteljanetz, Michael
Broholm, Helle
Højgaard, Liselotte
Law, Ian
Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours
title Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours
title_full Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours
title_fullStr Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours
title_full_unstemmed Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours
title_short Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours
title_sort brain perfusion ct compared with (15)o-h(2)o pet in patients with primary brain tumours
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464373/
https://www.ncbi.nlm.nih.gov/pubmed/22736199
http://dx.doi.org/10.1007/s00259-012-2173-1
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