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Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours
PURPOSE: Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF wit...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464373/ https://www.ncbi.nlm.nih.gov/pubmed/22736199 http://dx.doi.org/10.1007/s00259-012-2173-1 |
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author | Grüner, Julie Marie Paamand, Rune Kosteljanetz, Michael Broholm, Helle Højgaard, Liselotte Law, Ian |
author_facet | Grüner, Julie Marie Paamand, Rune Kosteljanetz, Michael Broholm, Helle Højgaard, Liselotte Law, Ian |
author_sort | Grüner, Julie Marie |
collection | PubMed |
description | PURPOSE: Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with (15)O-labelled water ((15)O-H(2)O). METHODS: On the same day within a few hours, rCBF was measured in ten adult patients with treatment-naïve primary brain tumours, twice using (15)O-H(2)O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared. RESULTS: PCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2 ± 18.8 ml min(−1) 100 ml(−1) for PET and 78.9 ± 41.8 ml min(−1) 100 ml(−1) for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9 ± 15.8 ml min(−1) 100 ml(−1) for low-grade (WHO I + II) and 81.5 ± 15.4 ml min(−1) 100 ml(−1) for high-grade (WHO III + IV) tumours, but not for PET. The rCBF PCT and PET correlation was only significant within tumours in two patients. CONCLUSION: Although intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and (15)O-H(2)O PET in brain tumours. |
format | Online Article Text |
id | pubmed-3464373 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-34643732012-10-05 Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours Grüner, Julie Marie Paamand, Rune Kosteljanetz, Michael Broholm, Helle Højgaard, Liselotte Law, Ian Eur J Nucl Med Mol Imaging Original Article PURPOSE: Perfusion CT (PCT) measurements of regional cerebral blood flow (rCBF) have been proposed as a fast and easy method for identifying angiogenically active tumours. In this study, quantitative PCT rCBF measurements in patients with brain tumours were compared to the gold standard PET rCBF with (15)O-labelled water ((15)O-H(2)O). METHODS: On the same day within a few hours, rCBF was measured in ten adult patients with treatment-naïve primary brain tumours, twice using (15)O-H(2)O PET and once with PCT performed over the central part of the tumour. Matching rCBF values in tumour and contralateral healthy regions of interest were compared. RESULTS: PCT overestimated intratumoural blood flow in all patients with volume-weighted mean rCBF values of 28.2 ± 18.8 ml min(−1) 100 ml(−1) for PET and 78.9 ± 41.8 ml min(−1) 100 ml(−1) for PCT. There was a significant method by tumour grade interaction with a significant tumour grade rCBF difference for PCT of 32.9 ± 15.8 ml min(−1) 100 ml(−1) for low-grade (WHO I + II) and 81.5 ± 15.4 ml min(−1) 100 ml(−1) for high-grade (WHO III + IV) tumours, but not for PET. The rCBF PCT and PET correlation was only significant within tumours in two patients. CONCLUSION: Although intratumoural blood flow measured by PCT may add valuable information on tumour grade, the method cannot substitute quantitative measurements of blood flow by PET and (15)O-H(2)O PET in brain tumours. Springer-Verlag 2012-06-27 2012 /pmc/articles/PMC3464373/ /pubmed/22736199 http://dx.doi.org/10.1007/s00259-012-2173-1 Text en © The Author(s) 2012 https://creativecommons.org/licenses/by/4.0/ This article is distributed under the terms of the Creative Commons Attribution License which permits any use, distribution, and reproduction in any medium, provided the original author(s) and the source are credited. |
spellingShingle | Original Article Grüner, Julie Marie Paamand, Rune Kosteljanetz, Michael Broholm, Helle Højgaard, Liselotte Law, Ian Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours |
title | Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours |
title_full | Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours |
title_fullStr | Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours |
title_full_unstemmed | Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours |
title_short | Brain perfusion CT compared with (15)O-H(2)O PET in patients with primary brain tumours |
title_sort | brain perfusion ct compared with (15)o-h(2)o pet in patients with primary brain tumours |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464373/ https://www.ncbi.nlm.nih.gov/pubmed/22736199 http://dx.doi.org/10.1007/s00259-012-2173-1 |
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