Conformational Flexibility Determines Selectivity and Antibacterial, Antiplasmodial, and Anticancer Potency of Cationic α-Helical Peptides

We used a combination of fluorescence, circular dichroism (CD), and NMR spectroscopies in conjunction with size exclusion chromatography to help rationalize the relative antibacterial, antiplasmodial, and cytotoxic activities of a series of proline-free and proline-containing model antimicrobial pep...

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Detalles Bibliográficos
Autores principales: Vermeer, Louic S., Lan, Yun, Abbate, Vincenzo, Ruh, Emrah, Bui, Tam T., Wilkinson, Louise J., Kanno, Tokuwa, Jumagulova, Elmira, Kozlowska, Justyna, Patel, Jayneil, McIntyre, Caitlin A., Yam, W. C., Siu, Gilman, Atkinson, R. Andrew, Lam, Jenny K. W., Bansal, Sukhvinder S., Drake, Alex F., Mitchell, Graham H., Mason, A. James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2012
Materias:
Membrane Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464521/
https://www.ncbi.nlm.nih.gov/pubmed/22869378
http://dx.doi.org/10.1074/jbc.M112.359067

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