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Precise Regulation of Porcupine Activity Is Required for Physiological Wnt Signaling

Gradients of diverse Wnt proteins regulate development, renewal, and differentiation. Porcupine (PORCN) is a membrane-bound O-acyltransferase that is required for post-translational modification of all Wnts to enable their transport, secretion, and activity. Mutations in PORCN are associated with fo...

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Detalles Bibliográficos
Autores principales:	Proffitt, Kyle D., Virshup, David M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Molecular Bases of Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464525/ https://www.ncbi.nlm.nih.gov/pubmed/22888000 http://dx.doi.org/10.1074/jbc.M112.381970

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