Cargando…

Inactivation of the Heme Degrading Enzyme IsdI by an Active Site Substitution That Diminishes Heme Ruffling

IsdG and IsdI are paralogous heme degrading enzymes from the bacterium Staphylococcus aureus. Heme bound by these enzymes is extensively ruffled such that the meso-carbons at the sites of oxidation are distorted toward bound oxygen. In contrast, the canonical heme oxygenase family degrades heme that...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ukpabi, Georgia, Takayama, Shin-ichi J., Mauk, A. Grant, Murphy, Michael E. P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2012
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464526/ https://www.ncbi.nlm.nih.gov/pubmed/22891243 http://dx.doi.org/10.1074/jbc.M112.393249

Ejemplares similares

Heme ligation and redox chemistry in two bacterial thiosulfate dehydrogenase (TsdA) enzymes
por: Jenner, Leon P., et al.
Publicado: (2019)

Secreted heme peroxidase from Dictyostelium discoideum: Insights into catalysis, structure, and biological role
por: Nicolussi, Andrea, et al.
Publicado: (2018)

Regulatory mechanism of formaldehyde release in heme degradation catalyzed by Staphylococcus aureus IsdG
por: Matsui, Toshitaka
Publicado: (2023)

Unique Heme-Iron Coordination by the Hemoglobin Receptor IsdB of Staphylococcus aureus
por: Gaudin, Catherine F. M., et al.
Publicado: (2011)

Caspase-1 Promiscuity Is Counterbalanced by Rapid Inactivation of Processed Enzyme
por: Walsh, John G., et al.
Publicado: (2011)

Chlamydomonas reinhardtii LFO1 Is an IsdG Family Heme Oxygenase
por: Lojek, Lisa J., et al.
Publicado: (2017)

O-Mucin-degrading carbohydrate-active enzymes and their possible implication in inflammatory bowel diseases
por: Labourel, Aurore, et al.
Publicado: (2023)

Non-Heme-Binding Domains and Segments of the Staphylococcus aureus IsdB Protein Critically Contribute to the Kinetics and Equilibrium of Heme Acquisition from Methemoglobin
por: Zhu, Hui, et al.
Publicado: (2014)

New mechanisms for bacterial degradation of sulfoquinovose
por: Wei, Yifeng, et al.
Publicado: (2022)

Cellulases Dig Deep: IN SITU OBSERVATION OF THE MESOSCOPIC STRUCTURAL DYNAMICS OF ENZYMATIC CELLULOSE DEGRADATION
por: Bubner, Patricia, et al.
Publicado: (2012)

Purification and Identification of Activating Enzymes of CS-0777, a Selective Sphingosine 1-Phosphate Receptor 1 Modulator, in Erythrocytes
por: Yonesu, Kiyoaki, et al.
Publicado: (2011)

Cryo-EM structures of staphylococcal IsdB bound to human hemoglobin reveal the process of heme extraction
por: De Bei, Omar, et al.
Publicado: (2022)

Cellulose Surface Degradation by a Lytic Polysaccharide Monooxygenase and Its Effect on Cellulase Hydrolytic Efficiency
por: Eibinger, Manuel, et al.
Publicado: (2014)

Structure and role of the linker domain of the iron surface-determinant protein IsdH in heme transportation in Staphylococcus aureus
por: Valenciano-Bellido, Sandra, et al.
Publicado: (2022)

Engineering enzyme catalysis: an inverse approach
por: Megarity, Clare F.
Publicado: (2019)

Probing altered enzyme activity in the biochemical characterization of cancer
por: Adam, Mowaffaq Adam Ahmed, et al.
Publicado: (2022)

Reconstitution of Formylglycine-generating Enzyme with Copper(II) for Aldehyde Tag Conversion
por: Holder, Patrick G., et al.
Publicado: (2015)

Structure and Mechanism of the Bifunctional CinA Enzyme from Thermus thermophilus
por: Karuppiah, Vijaykumar, et al.
Publicado: (2014)

Molecular and Thermodynamic Mechanisms of the Chloride-dependent Human Angiotensin-I-converting Enzyme (ACE)
por: Yates, Christopher J., et al.
Publicado: (2014)

A Conformational Sampling Model for Radical Catalysis in Pyridoxal Phosphate- and Cobalamin-dependent Enzymes
por: Menon, Binuraj R. K., et al.
Publicado: (2014)

Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-dependent Enzymes
por: Soo, Valerie W. C., et al.
Publicado: (2016)

The ever-expanding limits of enzyme catalysis and biodegradation: polyaromatic, polychlorinated, polyfluorinated, and polymeric compounds
por: Wackett, Lawrence P., et al.
Publicado: (2020)

SIRT1 Activation by Small Molecules: KINETIC AND BIOPHYSICAL EVIDENCE FOR DIRECT INTERACTION OF ENZYME AND ACTIVATOR
por: Dai, Han, et al.
Publicado: (2010)

Estradiol and progesterone affect enzymes but not glucose consumption in a mink uterine cell line (GMMe)
por: Holmlund, Hayden, et al.
Publicado: (2020)

Glucuronoyl esterases – enzymes to decouple lignin and carbohydrates and enable better utilization of renewable plant biomass
por: Larsbrink, Johan, et al.
Publicado: (2023)

Mechanism of Ferrous Iron Binding and Oxidation by Ferritin from a Pennate Diatom
por: Pfaffen, Stephanie, et al.
Publicado: (2013)

From Host Heme To Iron: The Expanding Spectrum of Heme Degrading Enzymes Used by Pathogenic Bacteria
por: Lyles, Kristin V., et al.
Publicado: (2018)

Stereochemical Features of Glutathione-dependent Enzymes in the Sphingobium sp. Strain SYK-6 β-Aryl Etherase Pathway
por: Gall, Daniel L., et al.
Publicado: (2014)

Oxidation of Monolignols by Members of the Berberine Bridge Enzyme Family Suggests a Role in Plant Cell Wall Metabolism
por: Daniel, Bastian, et al.
Publicado: (2015)

Biosynthesis of the sactipeptide Ruminococcin C by the human microbiome: Mechanistic insights into thioether bond formation by radical SAM enzymes
por: Balty, Clémence, et al.
Publicado: (2021)

NrdH-Redoxin Protein Mediates High Enzyme Activity in Manganese-reconstituted Ribonucleotide Reductase from Bacillus anthracis
por: Crona, Mikael, et al.
Publicado: (2011)

PqsBC, a Condensing Enzyme in the Biosynthesis of the Pseudomonas aeruginosa Quinolone Signal: CRYSTAL STRUCTURE, INHIBITION, AND REACTION MECHANISM
por: Drees, Steffen Lorenz, et al.
Publicado: (2016)

Structural and Kinetic Evidence That Catalytic Reaction of Human UDP-glucose 6-Dehydrogenase Involves Covalent Thiohemiacetal and Thioester Enzyme Intermediates
por: Egger, Sigrid, et al.
Publicado: (2012)

Galactomannan Catabolism Conferred by a Polysaccharide Utilization Locus of Bacteroides ovatus: ENZYME SYNERGY AND CRYSTAL STRUCTURE OF A β-MANNANASE
por: Bågenholm, Viktoria, et al.
Publicado: (2017)

Structural and spectroscopic analyses of the sporulation killing factor biosynthetic enzyme SkfB, a bacterial AdoMet radical sactisynthase
por: Grell, Tsehai A. J., et al.
Publicado: (2018)

Significance of Heme and Heme Degradation in the Pathogenesis of Acute Lung and Inflammatory Disorders
por: Ryter, Stefan W.
Publicado: (2021)

A noncanonical heme oxygenase specific for the degradation of c-type heme
por: Li, Shuxin, et al.
Publicado: (2021)

Peroxynitrite-mediated inactivation of heme oxygenases
por: Kinobe, Robert, et al.
Publicado: (2004)

A Diatom Ferritin Optimized for Iron Oxidation but Not Iron Storage
por: Pfaffen, Stephanie, et al.
Publicado: (2015)

The α- and β-Subunit Boundary at the Stem of the Mushroom-Like α(3)β(3)-Type Oxygenase Component of Rieske Non-Heme Iron Oxygenases Is the Rieske-Type Ferredoxin-Binding Site
por: Tsai, Pi-Cheng, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_vak1q3nfagd88eclu3iif20742