Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target

Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in different disease states playing both protecti...

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Detalles Bibliográficos
Autores principales: Vidyasagar, Aparna, Wilson, Nancy A, Djamali, Arjang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464729/
https://www.ncbi.nlm.nih.gov/pubmed/22564335
http://dx.doi.org/10.1186/1755-1536-5-7
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author Vidyasagar, Aparna
Wilson, Nancy A
Djamali, Arjang
author_facet Vidyasagar, Aparna
Wilson, Nancy A
Djamali, Arjang
author_sort Vidyasagar, Aparna
collection PubMed
description Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in different disease states playing both protective and counter-protective roles. The current review presents HSP27 in multiple disease contexts: renal injury and fibrosis, cancer, neuro-degenerative and cardiovascular disease, highlighting its role as a potential biomarker and therapeutic target.
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spelling pubmed-34647292012-10-05 Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target Vidyasagar, Aparna Wilson, Nancy A Djamali, Arjang Fibrogenesis Tissue Repair Review Heat shock protein 27 (HSP27) is a multidimensional protein which acts as a protein chaperone and an antioxidant and plays a role in the inhibition of apoptosis and actin cytoskeletal remodeling. In each of these capacities, HSP27 has been implicated in different disease states playing both protective and counter-protective roles. The current review presents HSP27 in multiple disease contexts: renal injury and fibrosis, cancer, neuro-degenerative and cardiovascular disease, highlighting its role as a potential biomarker and therapeutic target. BioMed Central 2012-05-07 /pmc/articles/PMC3464729/ /pubmed/22564335 http://dx.doi.org/10.1186/1755-1536-5-7 Text en Copyright ©2012 Vidyasagar et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Vidyasagar, Aparna
Wilson, Nancy A
Djamali, Arjang
Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target
title Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target
title_full Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target
title_fullStr Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target
title_full_unstemmed Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target
title_short Heat shock protein 27 (HSP27): biomarker of disease and therapeutic target
title_sort heat shock protein 27 (hsp27): biomarker of disease and therapeutic target
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464729/
https://www.ncbi.nlm.nih.gov/pubmed/22564335
http://dx.doi.org/10.1186/1755-1536-5-7
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