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Reduced lung function is independently associated with increased risk of type 2 diabetes in Korean men
BACKGROUND: Reduced lung function is associated with incident insulin resistance and diabetes. The aim of this study was to assess the relationship between lung function and incident type 2 diabetes in Korean men. METHODS: This study included 9,220 men (mean age: 41.4 years) without type 2 diabetes...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464774/ https://www.ncbi.nlm.nih.gov/pubmed/22524685 http://dx.doi.org/10.1186/1475-2840-11-38 |
Sumario: | BACKGROUND: Reduced lung function is associated with incident insulin resistance and diabetes. The aim of this study was to assess the relationship between lung function and incident type 2 diabetes in Korean men. METHODS: This study included 9,220 men (mean age: 41.4 years) without type 2 diabetes at baseline who were followed for five years. Subjects were divided into four groups according to baseline forced vital capacity (FVC) (% predicted) and forced expiratory volume in one second (FEV(1)) (% predicted) quartiles. The incidence of type 2 diabetes at follow-up was compared according to FVC and FEV(1) quartiles. RESULTS: The overall incidence of type 2 diabetes was 2.2%. Reduced lung function was significantly associated with the incidence of type 2 diabetes after adjusting for age, BMI, education, smoking, exercise, alcohol, and HOMA-IR. Both FVC and FEV(1) were negatively associated with type 2 diabetes (P < 0.05). In non-obese subjects with BMI < 25, the lowest quartile of FVC and FEV(1) had a significantly higher odds ratio for type 2 diabetes compared with the highest quartile after adjusting for age and BMI (2.15 [95% CI 1.02-4.57] and 2.19 [95% CI 1.09-4.42]). CONCLUSIONS: Reduced lung function is independently associated with the incidence of type 2 diabetes in Korean men. |
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