Overlapping effector interfaces define the multiple functions of the HIV-1 Nef polyproline helix

BACKGROUND: HIV-1 Nef is a multifunctional protein required for full pathogenicity of the virus. As Nef has no known enzymatic activity, it necessarily functions through protein-protein interaction interfaces. A critical Nef protein interaction interface is centered on its polyproline segment (P(69)...

Descripción completa

Detalles Bibliográficos
Autores principales: Kuo, Lillian S, Baugh, Laura L, Denial, Sarah J, Watkins, Richard L, Liu, Mingjie, Garcia, J Victor, Foster, John L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3464899/
https://www.ncbi.nlm.nih.gov/pubmed/22651890
http://dx.doi.org/10.1186/1742-4690-9-47

Ejemplares similares

Ejemplares similares