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Design and evaluation of colon targeted modified pulsincap delivery of 5-fluorouracil according to circadian rhythm
INTRODUCTION: A modified pulsincap dosage form of 5-fluorouracil was developed to target drug to colorectal carcinoma according to daily oscillations of rate-limiting metabolizing enzyme dihydropyrimidine dehydrogenase. MATERIALS AND METHODS: The capsule body was made water insoluble by exposing the...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Medknow Publications & Media Pvt Ltd
2011
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465138/ https://www.ncbi.nlm.nih.gov/pubmed/23071940 http://dx.doi.org/10.4103/2230-973X.85969 |