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Urinary N-acetyl-β-D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study

BACKGROUND: Renal failure is one of the most serious complications associated with autosomal dominant polycystic kidney disease (ADPKD). To date, early markers have failed to predict renal function deterioration at the early stages. This 1-year prospective study evaluated N-acetyl-β-D-glucosaminidas...

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Autores principales: Park, Hayne Cho, Hwang, Jin Ho, Kang, Ah-Young, Ro, Han, Kim, Myung-Gyu, An, Jung Nam, In Park, Ji, Kim, Seung Hyup, Yang, Jaeseok, Oh, Yun Kyu, Oh, Kook-Hwan, Noh, Jung Woo, Cheong, Hae Il, Hwang, Young-Hwan, Ahn, Curie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465238/
https://www.ncbi.nlm.nih.gov/pubmed/22935351
http://dx.doi.org/10.1186/1471-2369-13-93
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author Park, Hayne Cho
Hwang, Jin Ho
Kang, Ah-Young
Ro, Han
Kim, Myung-Gyu
An, Jung Nam
In Park, Ji
Kim, Seung Hyup
Yang, Jaeseok
Oh, Yun Kyu
Oh, Kook-Hwan
Noh, Jung Woo
Cheong, Hae Il
Hwang, Young-Hwan
Ahn, Curie
author_facet Park, Hayne Cho
Hwang, Jin Ho
Kang, Ah-Young
Ro, Han
Kim, Myung-Gyu
An, Jung Nam
In Park, Ji
Kim, Seung Hyup
Yang, Jaeseok
Oh, Yun Kyu
Oh, Kook-Hwan
Noh, Jung Woo
Cheong, Hae Il
Hwang, Young-Hwan
Ahn, Curie
author_sort Park, Hayne Cho
collection PubMed
description BACKGROUND: Renal failure is one of the most serious complications associated with autosomal dominant polycystic kidney disease (ADPKD). To date, early markers have failed to predict renal function deterioration at the early stages. This 1-year prospective study evaluated N-acetyl-β-D-glucosaminidase (NAG) as a new surrogate marker for renal function in ADPKD. METHODS: A total of 270 patients were enrolled in the study, and we measured urinary NAG, β2-microglobulin, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) prospectively for 1 year to compare their predictive values for renal function. RESULTS: Baseline urinary NAG/Cr was negatively correlated with estimated glomerular filtration rate (GFR) (r(2) = 0.153, P < 0.001) and positively correlated with total kidney volume (TKV) (r(2) = 0.113, P < 0.001). Among other biomarkers, urinary NAG/Cr better discriminated patients with decreased renal function from those with conserved renal function, showing the largest area under the curve (AUC 0.794). Immunohistochemical study revealed strong staining along the cyst-lining epithelial cells as well as the nearby compressed tubular epithelial cells. However, both single and repeated measurements of urinary NAG/Cr failed to predict renal function decline in 1 year. CONCLUSIONS: Urinary NAG/Cr may be a useful surrogate marker for renal function in ADPKD patients.
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spelling pubmed-34652382012-10-06 Urinary N-acetyl-β-D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study Park, Hayne Cho Hwang, Jin Ho Kang, Ah-Young Ro, Han Kim, Myung-Gyu An, Jung Nam In Park, Ji Kim, Seung Hyup Yang, Jaeseok Oh, Yun Kyu Oh, Kook-Hwan Noh, Jung Woo Cheong, Hae Il Hwang, Young-Hwan Ahn, Curie BMC Nephrol Research Article BACKGROUND: Renal failure is one of the most serious complications associated with autosomal dominant polycystic kidney disease (ADPKD). To date, early markers have failed to predict renal function deterioration at the early stages. This 1-year prospective study evaluated N-acetyl-β-D-glucosaminidase (NAG) as a new surrogate marker for renal function in ADPKD. METHODS: A total of 270 patients were enrolled in the study, and we measured urinary NAG, β2-microglobulin, neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) prospectively for 1 year to compare their predictive values for renal function. RESULTS: Baseline urinary NAG/Cr was negatively correlated with estimated glomerular filtration rate (GFR) (r(2) = 0.153, P < 0.001) and positively correlated with total kidney volume (TKV) (r(2) = 0.113, P < 0.001). Among other biomarkers, urinary NAG/Cr better discriminated patients with decreased renal function from those with conserved renal function, showing the largest area under the curve (AUC 0.794). Immunohistochemical study revealed strong staining along the cyst-lining epithelial cells as well as the nearby compressed tubular epithelial cells. However, both single and repeated measurements of urinary NAG/Cr failed to predict renal function decline in 1 year. CONCLUSIONS: Urinary NAG/Cr may be a useful surrogate marker for renal function in ADPKD patients. BioMed Central 2012-08-30 /pmc/articles/PMC3465238/ /pubmed/22935351 http://dx.doi.org/10.1186/1471-2369-13-93 Text en Copyright ©2012 Park et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Park, Hayne Cho
Hwang, Jin Ho
Kang, Ah-Young
Ro, Han
Kim, Myung-Gyu
An, Jung Nam
In Park, Ji
Kim, Seung Hyup
Yang, Jaeseok
Oh, Yun Kyu
Oh, Kook-Hwan
Noh, Jung Woo
Cheong, Hae Il
Hwang, Young-Hwan
Ahn, Curie
Urinary N-acetyl-β-D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study
title Urinary N-acetyl-β-D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study
title_full Urinary N-acetyl-β-D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study
title_fullStr Urinary N-acetyl-β-D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study
title_full_unstemmed Urinary N-acetyl-β-D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study
title_short Urinary N-acetyl-β-D glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study
title_sort urinary n-acetyl-β-d glucosaminidase as a surrogate marker for renal function in autosomal dominant polycystic kidney disease: 1 year prospective cohort study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465238/
https://www.ncbi.nlm.nih.gov/pubmed/22935351
http://dx.doi.org/10.1186/1471-2369-13-93
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