Small Molecule-Based Promotion of PKCα-Mediated β-Catenin Degradation Suppresses the Proliferation of CRT-Positive Cancer Cells

Aberrant accumulation of intracellular β-catenin is a well recognized characteristic of several cancers, including prostate, colon, and liver cancers, and is a potential target for development of anticancer therapeutics. Here, we used cell-based small molecule screening to identify CGK062 as an inhi...

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Detalles Bibliográficos
Autores principales: Gwak, Jungsug, Lee, Jee-Hyun, Chung, Young-Hwa, Song, Gyu-Yong, Oh, Sangtaek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465275/
https://www.ncbi.nlm.nih.gov/pubmed/23071615
http://dx.doi.org/10.1371/journal.pone.0046697

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465275/
https://www.ncbi.nlm.nih.gov/pubmed/23071615
http://dx.doi.org/10.1371/journal.pone.0046697

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