Breast cancer: from “maximum tolerable” to “minimum effective” treatment

Randomized trials have played a fundamental role in identifying better treatments for most type of diseases, especially in the oncological field. In breast cancer, the shift from “maximum tolerable” to “minimum effective” treatment has been evident since the 1970s and has been based on the results o...

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Detalles Bibliográficos
Autores principales: Veronesi, Umberto, Stafyla, Vaia, Luini, Alberto, Veronesi, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465814/
https://www.ncbi.nlm.nih.gov/pubmed/23061042
http://dx.doi.org/10.3389/fonc.2012.00125
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author Veronesi, Umberto
Stafyla, Vaia
Luini, Alberto
Veronesi, Paolo
author_facet Veronesi, Umberto
Stafyla, Vaia
Luini, Alberto
Veronesi, Paolo
author_sort Veronesi, Umberto
collection PubMed
description Randomized trials have played a fundamental role in identifying better treatments for most type of diseases, especially in the oncological field. In breast cancer, the shift from “maximum tolerable” to “minimum effective” treatment has been evident since the 1970s and has been based on the results of international randomized trials. The progress of breast surgery represents an excellent model of the evolution of science and the aim of this article is to review the main randomized studies that changed everyday practice in breast surgery.
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spelling pubmed-34658142012-10-11 Breast cancer: from “maximum tolerable” to “minimum effective” treatment Veronesi, Umberto Stafyla, Vaia Luini, Alberto Veronesi, Paolo Front Oncol Oncology Randomized trials have played a fundamental role in identifying better treatments for most type of diseases, especially in the oncological field. In breast cancer, the shift from “maximum tolerable” to “minimum effective” treatment has been evident since the 1970s and has been based on the results of international randomized trials. The progress of breast surgery represents an excellent model of the evolution of science and the aim of this article is to review the main randomized studies that changed everyday practice in breast surgery. Frontiers Media S.A. 2012-10-08 /pmc/articles/PMC3465814/ /pubmed/23061042 http://dx.doi.org/10.3389/fonc.2012.00125 Text en Copyright © 2012 Veronesi, Stafyla, Luini and Veronesi. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Oncology
Veronesi, Umberto
Stafyla, Vaia
Luini, Alberto
Veronesi, Paolo
Breast cancer: from “maximum tolerable” to “minimum effective” treatment
title Breast cancer: from “maximum tolerable” to “minimum effective” treatment
title_full Breast cancer: from “maximum tolerable” to “minimum effective” treatment
title_fullStr Breast cancer: from “maximum tolerable” to “minimum effective” treatment
title_full_unstemmed Breast cancer: from “maximum tolerable” to “minimum effective” treatment
title_short Breast cancer: from “maximum tolerable” to “minimum effective” treatment
title_sort breast cancer: from “maximum tolerable” to “minimum effective” treatment
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465814/
https://www.ncbi.nlm.nih.gov/pubmed/23061042
http://dx.doi.org/10.3389/fonc.2012.00125
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