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Facilitated/Pharmaco-invasive Approaches in STEMI

Primary percutaneous coronary intervention (PCI) is the preferred reperfusion method in patients with ST-elevation myocardial infarction (STEMI), when performed in a timely manner and by skilled operators. However, this strategy has shown to be limited in environments with lack of PCI facilities and...

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Detalles Bibliográficos
Autores principales: Capodanno, Davide, Dangas, George
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465821/
https://www.ncbi.nlm.nih.gov/pubmed/22920485
http://dx.doi.org/10.2174/157340312803217157
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author Capodanno, Davide
Dangas, George
author_facet Capodanno, Davide
Dangas, George
author_sort Capodanno, Davide
collection PubMed
description Primary percutaneous coronary intervention (PCI) is the preferred reperfusion method in patients with ST-elevation myocardial infarction (STEMI), when performed in a timely manner and by skilled operators. However, this strategy has shown to be limited in environments with lack of PCI facilities and delay in the first medical contact-to-balloon time for logistic reasons. Pretreatment with fibrinolysis and/or glycoprotein IIb/IIIa inhibitors before PCI has the potential to provide early pharmacologic reperfusion before definitive PCI in STEMI patients. However, current data suggest that facilitated PCI does not offer any advantage over primary PCI. Conversely, a role for pharmacoinvasive recanalization, defined as pharmacological reperfusion followed by rapid transfer for routine delayed coronary angiography and PCI may still be considered in centers without on-site PCI capability.
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spelling pubmed-34658212013-08-01 Facilitated/Pharmaco-invasive Approaches in STEMI Capodanno, Davide Dangas, George Curr Cardiol Rev Article Primary percutaneous coronary intervention (PCI) is the preferred reperfusion method in patients with ST-elevation myocardial infarction (STEMI), when performed in a timely manner and by skilled operators. However, this strategy has shown to be limited in environments with lack of PCI facilities and delay in the first medical contact-to-balloon time for logistic reasons. Pretreatment with fibrinolysis and/or glycoprotein IIb/IIIa inhibitors before PCI has the potential to provide early pharmacologic reperfusion before definitive PCI in STEMI patients. However, current data suggest that facilitated PCI does not offer any advantage over primary PCI. Conversely, a role for pharmacoinvasive recanalization, defined as pharmacological reperfusion followed by rapid transfer for routine delayed coronary angiography and PCI may still be considered in centers without on-site PCI capability. Bentham Science Publishers 2012-08 2012-08 /pmc/articles/PMC3465821/ /pubmed/22920485 http://dx.doi.org/10.2174/157340312803217157 Text en © 2012 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Article
Capodanno, Davide
Dangas, George
Facilitated/Pharmaco-invasive Approaches in STEMI
title Facilitated/Pharmaco-invasive Approaches in STEMI
title_full Facilitated/Pharmaco-invasive Approaches in STEMI
title_fullStr Facilitated/Pharmaco-invasive Approaches in STEMI
title_full_unstemmed Facilitated/Pharmaco-invasive Approaches in STEMI
title_short Facilitated/Pharmaco-invasive Approaches in STEMI
title_sort facilitated/pharmaco-invasive approaches in stemi
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465821/
https://www.ncbi.nlm.nih.gov/pubmed/22920485
http://dx.doi.org/10.2174/157340312803217157
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