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Facilitated/Pharmaco-invasive Approaches in STEMI
Primary percutaneous coronary intervention (PCI) is the preferred reperfusion method in patients with ST-elevation myocardial infarction (STEMI), when performed in a timely manner and by skilled operators. However, this strategy has shown to be limited in environments with lack of PCI facilities and...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Bentham Science Publishers
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465821/ https://www.ncbi.nlm.nih.gov/pubmed/22920485 http://dx.doi.org/10.2174/157340312803217157 |
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author | Capodanno, Davide Dangas, George |
author_facet | Capodanno, Davide Dangas, George |
author_sort | Capodanno, Davide |
collection | PubMed |
description | Primary percutaneous coronary intervention (PCI) is the preferred reperfusion method in patients with ST-elevation myocardial infarction (STEMI), when performed in a timely manner and by skilled operators. However, this strategy has shown to be limited in environments with lack of PCI facilities and delay in the first medical contact-to-balloon time for logistic reasons. Pretreatment with fibrinolysis and/or glycoprotein IIb/IIIa inhibitors before PCI has the potential to provide early pharmacologic reperfusion before definitive PCI in STEMI patients. However, current data suggest that facilitated PCI does not offer any advantage over primary PCI. Conversely, a role for pharmacoinvasive recanalization, defined as pharmacological reperfusion followed by rapid transfer for routine delayed coronary angiography and PCI may still be considered in centers without on-site PCI capability. |
format | Online Article Text |
id | pubmed-3465821 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Bentham Science Publishers |
record_format | MEDLINE/PubMed |
spelling | pubmed-34658212013-08-01 Facilitated/Pharmaco-invasive Approaches in STEMI Capodanno, Davide Dangas, George Curr Cardiol Rev Article Primary percutaneous coronary intervention (PCI) is the preferred reperfusion method in patients with ST-elevation myocardial infarction (STEMI), when performed in a timely manner and by skilled operators. However, this strategy has shown to be limited in environments with lack of PCI facilities and delay in the first medical contact-to-balloon time for logistic reasons. Pretreatment with fibrinolysis and/or glycoprotein IIb/IIIa inhibitors before PCI has the potential to provide early pharmacologic reperfusion before definitive PCI in STEMI patients. However, current data suggest that facilitated PCI does not offer any advantage over primary PCI. Conversely, a role for pharmacoinvasive recanalization, defined as pharmacological reperfusion followed by rapid transfer for routine delayed coronary angiography and PCI may still be considered in centers without on-site PCI capability. Bentham Science Publishers 2012-08 2012-08 /pmc/articles/PMC3465821/ /pubmed/22920485 http://dx.doi.org/10.2174/157340312803217157 Text en © 2012 Bentham Science Publishers http://creativecommons.org/licenses/by/2.5/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.5/), which permits unrestrictive use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Article Capodanno, Davide Dangas, George Facilitated/Pharmaco-invasive Approaches in STEMI |
title | Facilitated/Pharmaco-invasive Approaches in STEMI |
title_full | Facilitated/Pharmaco-invasive Approaches in STEMI |
title_fullStr | Facilitated/Pharmaco-invasive Approaches in STEMI |
title_full_unstemmed | Facilitated/Pharmaco-invasive Approaches in STEMI |
title_short | Facilitated/Pharmaco-invasive Approaches in STEMI |
title_sort | facilitated/pharmaco-invasive approaches in stemi |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465821/ https://www.ncbi.nlm.nih.gov/pubmed/22920485 http://dx.doi.org/10.2174/157340312803217157 |
work_keys_str_mv | AT capodannodavide facilitatedpharmacoinvasiveapproachesinstemi AT dangasgeorge facilitatedpharmacoinvasiveapproachesinstemi |