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Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease

The correlation of coronary artery disease (CAD) with pro-oxidant/antioxidant balance and oxidative DNA damage was investigated. Seventy-seven patients with CAD and 44 healthy individuals as control were included in this study. The comparative ratios of ubiquinol-10/ubiquinone-10, 8-hydroxy-2('...

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Autores principales: KAYA, Yüksel, ÇEBİ, Ayşegül, SÖYLEMEZ, Nihat, DEMİR, Halit, ALP, Hamit Hakan, BAKAN, Ebubekir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465845/
https://www.ncbi.nlm.nih.gov/pubmed/23055813
http://dx.doi.org/10.7150/ijms.4768
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author KAYA, Yüksel
ÇEBİ, Ayşegül
SÖYLEMEZ, Nihat
DEMİR, Halit
ALP, Hamit Hakan
BAKAN, Ebubekir
author_facet KAYA, Yüksel
ÇEBİ, Ayşegül
SÖYLEMEZ, Nihat
DEMİR, Halit
ALP, Hamit Hakan
BAKAN, Ebubekir
author_sort KAYA, Yüksel
collection PubMed
description The correlation of coronary artery disease (CAD) with pro-oxidant/antioxidant balance and oxidative DNA damage was investigated. Seventy-seven patients with CAD and 44 healthy individuals as control were included in this study. The comparative ratios of ubiquinol-10/ubiquinone-10, 8-hydroxy-2(')-deoxyguanosine/deoxyguanosine and the level of MDA measured by HPLC and the activities of GPX and SOD by colorimetric approach in blood samples obtained from patients with CAD were unraveled. 8-OHdG/dG ratios, serum MDA level and GPX activity were found significantly elevated level in serum of CAD patients compared to control group. The SOD activity was observed in stable levels in CAD patients. Ubiquinol-10/ubiquinone-10 ratio was significantly lower in patients with CAD than the controls. The positive correlation was observed between 8-OHdG/dG ratios in both MDA levels and GPX activity, while the significant negative correlation was seemed between the ratio of 8-OHdG/dG and ubiquinol-10/ ubiquinone-10 as well as MDA levels and ubiquinol-10/ ubiquinone-10 ratio. We conclude that, both the disruption of pro-oxidant/antioxidant balance and oxidative stress in DNA may play an important role in the pathogenesis of coronary artery disease.
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spelling pubmed-34658452012-10-09 Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease KAYA, Yüksel ÇEBİ, Ayşegül SÖYLEMEZ, Nihat DEMİR, Halit ALP, Hamit Hakan BAKAN, Ebubekir Int J Med Sci Research Paper The correlation of coronary artery disease (CAD) with pro-oxidant/antioxidant balance and oxidative DNA damage was investigated. Seventy-seven patients with CAD and 44 healthy individuals as control were included in this study. The comparative ratios of ubiquinol-10/ubiquinone-10, 8-hydroxy-2(')-deoxyguanosine/deoxyguanosine and the level of MDA measured by HPLC and the activities of GPX and SOD by colorimetric approach in blood samples obtained from patients with CAD were unraveled. 8-OHdG/dG ratios, serum MDA level and GPX activity were found significantly elevated level in serum of CAD patients compared to control group. The SOD activity was observed in stable levels in CAD patients. Ubiquinol-10/ubiquinone-10 ratio was significantly lower in patients with CAD than the controls. The positive correlation was observed between 8-OHdG/dG ratios in both MDA levels and GPX activity, while the significant negative correlation was seemed between the ratio of 8-OHdG/dG and ubiquinol-10/ ubiquinone-10 as well as MDA levels and ubiquinol-10/ ubiquinone-10 ratio. We conclude that, both the disruption of pro-oxidant/antioxidant balance and oxidative stress in DNA may play an important role in the pathogenesis of coronary artery disease. Ivyspring International Publisher 2012-09-19 /pmc/articles/PMC3465845/ /pubmed/23055813 http://dx.doi.org/10.7150/ijms.4768 Text en © Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License (http://creativecommons.org/licenses/by-nc-nd/3.0/). Reproduction is permitted for personal, noncommercial use, provided that the article is in whole, unmodified, and properly cited.
spellingShingle Research Paper
KAYA, Yüksel
ÇEBİ, Ayşegül
SÖYLEMEZ, Nihat
DEMİR, Halit
ALP, Hamit Hakan
BAKAN, Ebubekir
Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease
title Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease
title_full Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease
title_fullStr Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease
title_full_unstemmed Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease
title_short Correlations between Oxidative DNA Damage, Oxidative Stress and Coenzyme Q10 in Patients with Coronary Artery Disease
title_sort correlations between oxidative dna damage, oxidative stress and coenzyme q10 in patients with coronary artery disease
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465845/
https://www.ncbi.nlm.nih.gov/pubmed/23055813
http://dx.doi.org/10.7150/ijms.4768
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