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The Yin and Yang of Nicotine: Harmful during Development, Beneficial in Adult Patient Populations

Nicotine has remarkably diverse effects on the brain. Being the main active compound in tobacco, nicotine can aversively affect brain development. However, it has the ability to act positively by restoring attentional capabilities in smokers. Here, we focus on nicotine exposure during the prenatal a...

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Detalles Bibliográficos
Autores principales: Counotte, Danielle S., Smit, August B., Spijker, Sabine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465852/
https://www.ncbi.nlm.nih.gov/pubmed/23060798
http://dx.doi.org/10.3389/fphar.2012.00180
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author Counotte, Danielle S.
Smit, August B.
Spijker, Sabine
author_facet Counotte, Danielle S.
Smit, August B.
Spijker, Sabine
author_sort Counotte, Danielle S.
collection PubMed
description Nicotine has remarkably diverse effects on the brain. Being the main active compound in tobacco, nicotine can aversively affect brain development. However, it has the ability to act positively by restoring attentional capabilities in smokers. Here, we focus on nicotine exposure during the prenatal and adolescent developmental periods and specifically, we will review the long-lasting effects of nicotine on attention, both in humans and animal models. We discuss the reciprocal relation of the beneficial effects of nicotine, improving attention in smokers and in patients with neuropsychiatric diseases, such as schizophrenia and attention deficit/hyperactivity disorder, vs. nicotine-related attention deficits already caused during adolescence. Given the need for research on the mechanisms of nicotine’s cognitive actions, we discuss some of the recent work performed in animals.
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spelling pubmed-34658522012-10-11 The Yin and Yang of Nicotine: Harmful during Development, Beneficial in Adult Patient Populations Counotte, Danielle S. Smit, August B. Spijker, Sabine Front Pharmacol Pharmacology Nicotine has remarkably diverse effects on the brain. Being the main active compound in tobacco, nicotine can aversively affect brain development. However, it has the ability to act positively by restoring attentional capabilities in smokers. Here, we focus on nicotine exposure during the prenatal and adolescent developmental periods and specifically, we will review the long-lasting effects of nicotine on attention, both in humans and animal models. We discuss the reciprocal relation of the beneficial effects of nicotine, improving attention in smokers and in patients with neuropsychiatric diseases, such as schizophrenia and attention deficit/hyperactivity disorder, vs. nicotine-related attention deficits already caused during adolescence. Given the need for research on the mechanisms of nicotine’s cognitive actions, we discuss some of the recent work performed in animals. Frontiers Media S.A. 2012-10-08 /pmc/articles/PMC3465852/ /pubmed/23060798 http://dx.doi.org/10.3389/fphar.2012.00180 Text en Copyright © 2012 Counotte, Smit and Spijker. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc.
spellingShingle Pharmacology
Counotte, Danielle S.
Smit, August B.
Spijker, Sabine
The Yin and Yang of Nicotine: Harmful during Development, Beneficial in Adult Patient Populations
title The Yin and Yang of Nicotine: Harmful during Development, Beneficial in Adult Patient Populations
title_full The Yin and Yang of Nicotine: Harmful during Development, Beneficial in Adult Patient Populations
title_fullStr The Yin and Yang of Nicotine: Harmful during Development, Beneficial in Adult Patient Populations
title_full_unstemmed The Yin and Yang of Nicotine: Harmful during Development, Beneficial in Adult Patient Populations
title_short The Yin and Yang of Nicotine: Harmful during Development, Beneficial in Adult Patient Populations
title_sort yin and yang of nicotine: harmful during development, beneficial in adult patient populations
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465852/
https://www.ncbi.nlm.nih.gov/pubmed/23060798
http://dx.doi.org/10.3389/fphar.2012.00180
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