Cargando…
DNA-Binding and Topoisomerase-I-Suppressing Activities of Novel Vanadium Compound Van-7
Vanadium compounds were studied during recent years to be considered as a representative of a new class of nonplatinum metal anticancer agents in combination to its low toxicity. Here, we found a vanadium compound Van-7 as an inhibitor of Topo I other than Topo II using topoisomerase-mediated superc...
Autores principales: | Mo, Xiao-mei, Chen, Zhan-fang, Qi, Xin, Li, Yan-tuan, Li, Jing |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465879/ https://www.ncbi.nlm.nih.gov/pubmed/23055949 http://dx.doi.org/10.1155/2012/756374 |
Ejemplares similares
-
CK2-Mediated Hyperphosphorylation of Topoisomerase I Targets Serine 506, Enhances Topoisomerase I–DNA Binding, and Increases Cellular Camptothecin Sensitivity
por: Bandyopadhyay, Keya, et al.
Publicado: (2012) -
Evodiamine Stabilizes Topoisomerase I-DNA Cleavable Complex to Inhibit Topoisomerase I Activity
por: Chan, Agnes L.-F., et al.
Publicado: (2009) -
Vanadium compounds in medicine
por: Pessoa, Joao Costa, et al.
Publicado: (2015) -
Transcriptional repression by a secondary DNA binding surface of DNA topoisomerase I safeguards against hypertranscription
por: Lau, Mei Sheng, et al.
Publicado: (2023) -
Structural basis for suppression of hypernegative DNA supercoiling by E. coli topoisomerase I
por: Tan, Kemin, et al.
Publicado: (2015)