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Intravenous Immunoglobulin in the Management of Lupus Nephritis

The occurrence of nephritis in patients with systemic lupus erythematosus is associated with increased morbidity and mortality. The pathogenesis of lupus nephritis is complex, involving innate and adaptive cellular and humoral immune responses. Autoantibodies in particular have been shown to be crit...

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Detalles Bibliográficos
Autores principales: Wenderfer, Scott E., Thacker, Trisha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465901/
https://www.ncbi.nlm.nih.gov/pubmed/23056926
http://dx.doi.org/10.1155/2012/589359
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author Wenderfer, Scott E.
Thacker, Trisha
author_facet Wenderfer, Scott E.
Thacker, Trisha
author_sort Wenderfer, Scott E.
collection PubMed
description The occurrence of nephritis in patients with systemic lupus erythematosus is associated with increased morbidity and mortality. The pathogenesis of lupus nephritis is complex, involving innate and adaptive cellular and humoral immune responses. Autoantibodies in particular have been shown to be critical in the initiation and progression of renal injury, via interactions with both Fc-receptors and complement. One approach in the management of patients with lupus nephritis has been the use of intravenous immunoglobulin. This therapy has shown benefit in the setting of many forms of autoantibody-mediated injury; however, the mechanisms of efficacy are not fully understood. In this paper, the data supporting the use of immunoglobulin therapy in lupus nephritis will be evaluated. In addition, the potential mechanisms of action will be discussed with respect to the known involvement of complement and Fc-receptors in the kidney parenchyma. Results are provocative and warrant additional clinical trials.
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spelling pubmed-34659012012-10-10 Intravenous Immunoglobulin in the Management of Lupus Nephritis Wenderfer, Scott E. Thacker, Trisha Autoimmune Dis Review Article The occurrence of nephritis in patients with systemic lupus erythematosus is associated with increased morbidity and mortality. The pathogenesis of lupus nephritis is complex, involving innate and adaptive cellular and humoral immune responses. Autoantibodies in particular have been shown to be critical in the initiation and progression of renal injury, via interactions with both Fc-receptors and complement. One approach in the management of patients with lupus nephritis has been the use of intravenous immunoglobulin. This therapy has shown benefit in the setting of many forms of autoantibody-mediated injury; however, the mechanisms of efficacy are not fully understood. In this paper, the data supporting the use of immunoglobulin therapy in lupus nephritis will be evaluated. In addition, the potential mechanisms of action will be discussed with respect to the known involvement of complement and Fc-receptors in the kidney parenchyma. Results are provocative and warrant additional clinical trials. Hindawi Publishing Corporation 2012 2012-09-27 /pmc/articles/PMC3465901/ /pubmed/23056926 http://dx.doi.org/10.1155/2012/589359 Text en Copyright © 2012 S. E. Wenderfer and T. Thacker. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Wenderfer, Scott E.
Thacker, Trisha
Intravenous Immunoglobulin in the Management of Lupus Nephritis
title Intravenous Immunoglobulin in the Management of Lupus Nephritis
title_full Intravenous Immunoglobulin in the Management of Lupus Nephritis
title_fullStr Intravenous Immunoglobulin in the Management of Lupus Nephritis
title_full_unstemmed Intravenous Immunoglobulin in the Management of Lupus Nephritis
title_short Intravenous Immunoglobulin in the Management of Lupus Nephritis
title_sort intravenous immunoglobulin in the management of lupus nephritis
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3465901/
https://www.ncbi.nlm.nih.gov/pubmed/23056926
http://dx.doi.org/10.1155/2012/589359
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