Cargando…
Structure and Biosynthesis of the Antibiotic Bottromycin D
[Image: see text] Drug resistant infectious diseases are quickly becoming a global health crisis. While Streptomyces spp. have been a major source of antibiotics over the past 50 years, efficient methods are needed to identify new antibiotics and greatly improve the rate of discovery. LCMS-based met...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2012
|
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466018/ https://www.ncbi.nlm.nih.gov/pubmed/22984777 http://dx.doi.org/10.1021/ol3022758 |
| _version_ | 1782245625040994304 |
|---|---|
| author | Hou, Yanpeng Tianero, Ma. Diarey B. Kwan, Jason C. Wyche, Thomas P. Michel, Cole R. Ellis, Gregory A. Vazquez-Rivera, Emmanuel Braun, Doug R. Rose, Warren E. Schmidt, Eric W. Bugni, Tim S. |
| author_facet | Hou, Yanpeng Tianero, Ma. Diarey B. Kwan, Jason C. Wyche, Thomas P. Michel, Cole R. Ellis, Gregory A. Vazquez-Rivera, Emmanuel Braun, Doug R. Rose, Warren E. Schmidt, Eric W. Bugni, Tim S. |
| author_sort | Hou, Yanpeng |
| collection | PubMed |
| description | [Image: see text] Drug resistant infectious diseases are quickly becoming a global health crisis. While Streptomyces spp. have been a major source of antibiotics over the past 50 years, efficient methods are needed to identify new antibiotics and greatly improve the rate of discovery. LCMS-based metabolomics were applied to analyze extracts of 50 Streptomyes spp. Using this methodology, we discovered bottromycin D and used whole genome sequencing to determine its biosynthesis by a ribosomal pathway. |
| format | Online Article Text |
| id | pubmed-3466018 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2012 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-34660182012-10-08 Structure and Biosynthesis of the Antibiotic Bottromycin D Hou, Yanpeng Tianero, Ma. Diarey B. Kwan, Jason C. Wyche, Thomas P. Michel, Cole R. Ellis, Gregory A. Vazquez-Rivera, Emmanuel Braun, Doug R. Rose, Warren E. Schmidt, Eric W. Bugni, Tim S. Org Lett [Image: see text] Drug resistant infectious diseases are quickly becoming a global health crisis. While Streptomyces spp. have been a major source of antibiotics over the past 50 years, efficient methods are needed to identify new antibiotics and greatly improve the rate of discovery. LCMS-based metabolomics were applied to analyze extracts of 50 Streptomyes spp. Using this methodology, we discovered bottromycin D and used whole genome sequencing to determine its biosynthesis by a ribosomal pathway. American Chemical Society 2012-09-17 2012-10-05 /pmc/articles/PMC3466018/ /pubmed/22984777 http://dx.doi.org/10.1021/ol3022758 Text en Copyright © 2012 American Chemical Society http://pubs.acs.org This is an open-access article distributed under the ACS AuthorChoice Terms & Conditions. Any use of this article, must conform to the terms of that license which are available at http://pubs.acs.org. |
| spellingShingle | Hou, Yanpeng Tianero, Ma. Diarey B. Kwan, Jason C. Wyche, Thomas P. Michel, Cole R. Ellis, Gregory A. Vazquez-Rivera, Emmanuel Braun, Doug R. Rose, Warren E. Schmidt, Eric W. Bugni, Tim S. Structure and Biosynthesis of the Antibiotic Bottromycin D |
| title | Structure and Biosynthesis of the Antibiotic Bottromycin D |
| title_full | Structure and Biosynthesis of the Antibiotic Bottromycin D |
| title_fullStr | Structure and Biosynthesis of the Antibiotic Bottromycin D |
| title_full_unstemmed | Structure and Biosynthesis of the Antibiotic Bottromycin D |
| title_short | Structure and Biosynthesis of the Antibiotic Bottromycin D |
| title_sort | structure and biosynthesis of the antibiotic bottromycin d |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466018/ https://www.ncbi.nlm.nih.gov/pubmed/22984777 http://dx.doi.org/10.1021/ol3022758 |
| work_keys_str_mv | AT houyanpeng structureandbiosynthesisoftheantibioticbottromycind AT tianeromadiareyb structureandbiosynthesisoftheantibioticbottromycind AT kwanjasonc structureandbiosynthesisoftheantibioticbottromycind AT wychethomasp structureandbiosynthesisoftheantibioticbottromycind AT michelcoler structureandbiosynthesisoftheantibioticbottromycind AT ellisgregorya structureandbiosynthesisoftheantibioticbottromycind AT vazquezriveraemmanuel structureandbiosynthesisoftheantibioticbottromycind AT braundougr structureandbiosynthesisoftheantibioticbottromycind AT rosewarrene structureandbiosynthesisoftheantibioticbottromycind AT schmidtericw structureandbiosynthesisoftheantibioticbottromycind AT bugnitims structureandbiosynthesisoftheantibioticbottromycind |