Cargando…

Long-term oxytocin administration improves social behaviors in a girl with autistic disorder

BACKGROUND: Patients with autism spectrum disorders (ASDs) exhibit core autistic symptoms including social impairments from early childhood and mostly show secondary disabilities such as irritability and aggressive behavior based on core symptoms. However, there are still no radical treatments of so...

Descripción completa

Detalles Bibliográficos
Autores principales: Kosaka, Hirotaka, Munesue, Toshio, Ishitobi, Makoto, Asano, Mizuki, Omori, Masao, Sato, Makoto, Tomoda, Akemi, Wada, Yuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466125/
https://www.ncbi.nlm.nih.gov/pubmed/22888794
http://dx.doi.org/10.1186/1471-244X-12-110
_version_ 1782245630146510848
author Kosaka, Hirotaka
Munesue, Toshio
Ishitobi, Makoto
Asano, Mizuki
Omori, Masao
Sato, Makoto
Tomoda, Akemi
Wada, Yuji
author_facet Kosaka, Hirotaka
Munesue, Toshio
Ishitobi, Makoto
Asano, Mizuki
Omori, Masao
Sato, Makoto
Tomoda, Akemi
Wada, Yuji
author_sort Kosaka, Hirotaka
collection PubMed
description BACKGROUND: Patients with autism spectrum disorders (ASDs) exhibit core autistic symptoms including social impairments from early childhood and mostly show secondary disabilities such as irritability and aggressive behavior based on core symptoms. However, there are still no radical treatments of social impairments in these patients. Oxytocin has been reported to play important roles in multiple social behaviors dependent on social recognition, and has been expected as one of the effective treatments of social impairments of patients with ASDs. CASE PRESENTATION: We present a case of a 16-year-old girl with autistic disorder who treated by long-term administration of oxytocin nasal spray. Her autistic symptoms were successfully treated by two month administration; the girl’s social interactions and social communication began to improve without adverse effects. Her irritability and aggressive behavior also improved dramatically with marked decreases in aberrant behavior checklist scores from 69 to 7. CONCLUSION: This case is the first to illustrate long-term administration of oxytocin nasal spray in the targeted treatment of social impairments in a female with autistic disorder. This case suggests that long-term nasal oxytocin spray is promising and well-tolerated for treatment of social impairments of patients with ASDs.
format Online
Article
Text
id pubmed-3466125
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-34661252012-10-09 Long-term oxytocin administration improves social behaviors in a girl with autistic disorder Kosaka, Hirotaka Munesue, Toshio Ishitobi, Makoto Asano, Mizuki Omori, Masao Sato, Makoto Tomoda, Akemi Wada, Yuji BMC Psychiatry Case Report BACKGROUND: Patients with autism spectrum disorders (ASDs) exhibit core autistic symptoms including social impairments from early childhood and mostly show secondary disabilities such as irritability and aggressive behavior based on core symptoms. However, there are still no radical treatments of social impairments in these patients. Oxytocin has been reported to play important roles in multiple social behaviors dependent on social recognition, and has been expected as one of the effective treatments of social impairments of patients with ASDs. CASE PRESENTATION: We present a case of a 16-year-old girl with autistic disorder who treated by long-term administration of oxytocin nasal spray. Her autistic symptoms were successfully treated by two month administration; the girl’s social interactions and social communication began to improve without adverse effects. Her irritability and aggressive behavior also improved dramatically with marked decreases in aberrant behavior checklist scores from 69 to 7. CONCLUSION: This case is the first to illustrate long-term administration of oxytocin nasal spray in the targeted treatment of social impairments in a female with autistic disorder. This case suggests that long-term nasal oxytocin spray is promising and well-tolerated for treatment of social impairments of patients with ASDs. BioMed Central 2012-08-13 /pmc/articles/PMC3466125/ /pubmed/22888794 http://dx.doi.org/10.1186/1471-244X-12-110 Text en Copyright ©2012 Kosaka et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Kosaka, Hirotaka
Munesue, Toshio
Ishitobi, Makoto
Asano, Mizuki
Omori, Masao
Sato, Makoto
Tomoda, Akemi
Wada, Yuji
Long-term oxytocin administration improves social behaviors in a girl with autistic disorder
title Long-term oxytocin administration improves social behaviors in a girl with autistic disorder
title_full Long-term oxytocin administration improves social behaviors in a girl with autistic disorder
title_fullStr Long-term oxytocin administration improves social behaviors in a girl with autistic disorder
title_full_unstemmed Long-term oxytocin administration improves social behaviors in a girl with autistic disorder
title_short Long-term oxytocin administration improves social behaviors in a girl with autistic disorder
title_sort long-term oxytocin administration improves social behaviors in a girl with autistic disorder
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466125/
https://www.ncbi.nlm.nih.gov/pubmed/22888794
http://dx.doi.org/10.1186/1471-244X-12-110
work_keys_str_mv AT kosakahirotaka longtermoxytocinadministrationimprovessocialbehaviorsinagirlwithautisticdisorder
AT munesuetoshio longtermoxytocinadministrationimprovessocialbehaviorsinagirlwithautisticdisorder
AT ishitobimakoto longtermoxytocinadministrationimprovessocialbehaviorsinagirlwithautisticdisorder
AT asanomizuki longtermoxytocinadministrationimprovessocialbehaviorsinagirlwithautisticdisorder
AT omorimasao longtermoxytocinadministrationimprovessocialbehaviorsinagirlwithautisticdisorder
AT satomakoto longtermoxytocinadministrationimprovessocialbehaviorsinagirlwithautisticdisorder
AT tomodaakemi longtermoxytocinadministrationimprovessocialbehaviorsinagirlwithautisticdisorder
AT wadayuji longtermoxytocinadministrationimprovessocialbehaviorsinagirlwithautisticdisorder