Flexible trial design in practice - stopping arms for lack-of-benefit and adding research arms mid-trial in STAMPEDE: a multi-arm multi-stage randomized controlled trial

BACKGROUND: Systemic Therapy for Advanced or Metastatic Prostate cancer: Evaluation of Drug Efficacy (STAMPEDE) is a randomized controlled trial that follows a novel multi-arm, multi-stage (MAMS) design. We describe methodological and practical issues arising with (1) stopping recruitment to researc...

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Detalles Bibliográficos
Autores principales: Sydes, Matthew R, Parmar, Mahesh KB, Mason, Malcolm D, Clarke, Noel W, Amos, Claire, Anderson, John, de Bono, Johann, Dearnaley, David P, Dwyer, John, Green, Charlene, Jovic, Gordana, Ritchie, Alastair WS, Russell, J Martin, Sanders, Karen, Thalmann, George, James, Nicholas D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2012
Materias:
Methodology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466132/
https://www.ncbi.nlm.nih.gov/pubmed/22978443
http://dx.doi.org/10.1186/1745-6215-13-168

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