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Spinal metastasis in thyroid cancer
BACKGROUND: Thyroid carcinoma generally responds well to treatment and spinal metastasis is an uncommon feature. Many studies have looked at the management of spinal metastasis and proposed treatments, plans and algorithms. These range from well-established methods to potentially novel alternatives...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466148/ https://www.ncbi.nlm.nih.gov/pubmed/22730910 http://dx.doi.org/10.1186/1758-3284-4-39 |
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author | Ramadan, Sami Ugas, Mohamed A Berwick, Richard J Notay, Manisha Cho, Hyongyu Jerjes, Waseem Giannoudis, Peter V |
author_facet | Ramadan, Sami Ugas, Mohamed A Berwick, Richard J Notay, Manisha Cho, Hyongyu Jerjes, Waseem Giannoudis, Peter V |
author_sort | Ramadan, Sami |
collection | PubMed |
description | BACKGROUND: Thyroid carcinoma generally responds well to treatment and spinal metastasis is an uncommon feature. Many studies have looked at the management of spinal metastasis and proposed treatments, plans and algorithms. These range from well-established methods to potentially novel alternatives including bisphosphonates and vascular endothelial growth factor (VEGF) therapy, amongst others. The purposes of this systematic review of the literature are twofold. Firstly we sought to analyse the proposed management options in the literature. Then, secondly, we endeavoured to make recommendations that might improve the prognosis of patients with spinal metastasis from thyroid carcinomas. METHODS: We conducted an extensive electronic literature review regarding the management of spinal metastasis of thyroid cancer. RESULTS: We found that there is a tangible lack of studies specifically analysing the management of spinal metastasis in thyroid cancer. Our results show that there are palliative and curative options in the management of spinal metastasis, in the forms of radioiodine ablation, surgery, selective embolisation, bisphosphonates and more recently the VEGF receptor targets. CONCLUSIONS: The management of spinal metastasis from thyroid cancer should be multi-disciplinary. There is an absence; it seems, of a definitive protocol for treatment. Research shows increased survival with (131)I avidity and complete bone metastasis resection. Early detection and treatment therefore are crucial. Studies suggest in those patients below the age of 45 years that treatment should be aggressive, and aim for cure. In those patients in whom curative treatment is not an option, palliative treatments are available. |
format | Online Article Text |
id | pubmed-3466148 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-34661482012-10-09 Spinal metastasis in thyroid cancer Ramadan, Sami Ugas, Mohamed A Berwick, Richard J Notay, Manisha Cho, Hyongyu Jerjes, Waseem Giannoudis, Peter V Head Neck Oncol Research BACKGROUND: Thyroid carcinoma generally responds well to treatment and spinal metastasis is an uncommon feature. Many studies have looked at the management of spinal metastasis and proposed treatments, plans and algorithms. These range from well-established methods to potentially novel alternatives including bisphosphonates and vascular endothelial growth factor (VEGF) therapy, amongst others. The purposes of this systematic review of the literature are twofold. Firstly we sought to analyse the proposed management options in the literature. Then, secondly, we endeavoured to make recommendations that might improve the prognosis of patients with spinal metastasis from thyroid carcinomas. METHODS: We conducted an extensive electronic literature review regarding the management of spinal metastasis of thyroid cancer. RESULTS: We found that there is a tangible lack of studies specifically analysing the management of spinal metastasis in thyroid cancer. Our results show that there are palliative and curative options in the management of spinal metastasis, in the forms of radioiodine ablation, surgery, selective embolisation, bisphosphonates and more recently the VEGF receptor targets. CONCLUSIONS: The management of spinal metastasis from thyroid cancer should be multi-disciplinary. There is an absence; it seems, of a definitive protocol for treatment. Research shows increased survival with (131)I avidity and complete bone metastasis resection. Early detection and treatment therefore are crucial. Studies suggest in those patients below the age of 45 years that treatment should be aggressive, and aim for cure. In those patients in whom curative treatment is not an option, palliative treatments are available. BioMed Central 2012-06-25 /pmc/articles/PMC3466148/ /pubmed/22730910 http://dx.doi.org/10.1186/1758-3284-4-39 Text en Copyright © 2012 Ramadan et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Ramadan, Sami Ugas, Mohamed A Berwick, Richard J Notay, Manisha Cho, Hyongyu Jerjes, Waseem Giannoudis, Peter V Spinal metastasis in thyroid cancer |
title | Spinal metastasis in thyroid cancer |
title_full | Spinal metastasis in thyroid cancer |
title_fullStr | Spinal metastasis in thyroid cancer |
title_full_unstemmed | Spinal metastasis in thyroid cancer |
title_short | Spinal metastasis in thyroid cancer |
title_sort | spinal metastasis in thyroid cancer |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466148/ https://www.ncbi.nlm.nih.gov/pubmed/22730910 http://dx.doi.org/10.1186/1758-3284-4-39 |
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