EGFR Inhibition Abrogates Leiomyosarcoma Cell Chemoresistance through Inactivation of Survival Pathways and Impairment of CSC Potential

BACKGROUND: Tumor cells with stem-like phenotype and properties, known as cancer stem cells (CSC), have been identified in most solid tumors and are presumed to be responsible for driving tumor initiation, chemoresistance, relapse, or metastasis. A subpopulation of cells with increased stem-like pot...

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Detalles Bibliográficos
Autores principales: Sette, Giovanni, Salvati, Valentina, Memeo, Lorenzo, Fecchi, Katia, Colarossi, Cristina, Di Matteo, Paola, Signore, Michele, Biffoni, Mauro, D’Andrea, Vito, De Antoni, Enrico, Canzonieri, Vincenzo, De Maria, Ruggero, Eramo, Adriana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466184/
https://www.ncbi.nlm.nih.gov/pubmed/23056514
http://dx.doi.org/10.1371/journal.pone.0046891

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