Cargando…

Phase I Randomized Safety Study of Twice Daily Dosing of Acidform Vaginal Gel: Candidate Antimicrobial Contraceptive

BACKGROUND: Acidform gel, an acid-buffering product that inactivates spermatozoa, may be an effective topical non-hormonal contraceptive. This study was designed to evaluate the safety of vaginal dosing and effects of Acidform on mucosal immune mediators, antimicrobial properties of genital secretio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Keller, Marla J., Carpenter, Colleen A., Lo, Yungtai, Einstein, Mark H., Liu, Congzhou, Fredricks, David N., Herold, Betsy C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466198/ https://www.ncbi.nlm.nih.gov/pubmed/23056520 http://dx.doi.org/10.1371/journal.pone.0046901

Ejemplares similares

Altered Biomarkers of Mucosal Immunity and Reduced Vaginal Lactobacillus Concentrations in Sexually Active Female Adolescents
por: Madan, Rebecca Pellett, et al.
Publicado: (2012)

Twice-Daily Application of HIV Microbicides Alters the Vaginal Microbiota
por: Ravel, Jacques, et al.
Publicado: (2012)

Lactobacillus crispatus Dominant Vaginal Microbiome Is Associated with Inhibitory Activity of Female Genital Tract Secretions against Escherichia coli
por: Ghartey, Jeny P., et al.
Publicado: (2014)

Vaginal bacteria elicit acute inflammatory response in fallopian tube organoids: a model for pelvic inflammatory disease
por: Yu, Bo, et al.
Publicado: (2023)

Temporal Variability of Human Vaginal Bacteria and Relationship with Bacterial Vaginosis
por: Srinivasan, Sujatha, et al.
Publicado: (2010)

Lactobacillus Proteins Are Associated with the Bactericidal Activity against E. coli of Female Genital Tract Secretions
por: Kalyoussef, Sabah, et al.
Publicado: (2012)

Practical guide to choosing dabigatran 150 mg twice daily or apixaban 5 mg twice daily for patients with atrial fibrillation
por: Kobayashi, Zen, et al.
Publicado: (2019)

Advances in contraception: vaginal contraceptive rings
por: Al-Haddad, Sara, et al.
Publicado: (2023)

Once– versus twice–daily tacrolimus: are the formulations equivalent?
por: Ciszek, Michał
Publicado: (2013)

Daily Vaginal Microbiota Fluctuations Associated with Natural Hormonal Cycle, Contraceptives, Diet, and Exercise
por: Song, Stephanie D., et al.
Publicado: (2020)

Development of pre-clinical and clinical models to predict the efficacy and safety of vaginal microbicides
por: Herold, Betsy C
Publicado: (2006)

Comparison of once daily versus twice daily olmesartan in patients with chronic kidney disease
por: Sakai, Yukinao, et al.
Publicado: (2013)

Twice Daily Prazosin and Valproic Acid in the Treatment of Flashbacks in PTSD
por: Fisher, Kristy A., et al.
Publicado: (2022)

More Than Meets the Eye: Associations of Vaginal Bacteria with Gram Stain Morphotypes Using Molecular Phylogenetic Analysis
por: Srinivasan, Sujatha, et al.
Publicado: (2013)

Randomized, double-blind, noninferiority study of diclofenac diethylamine 2.32% gel applied twice daily versus diclofenac diethylamine 1.16% gel applied four times daily in patients with acute ankle sprain
por: Yin, Feng, et al.
Publicado: (2022)

A Phase I Randomized Placebo Controlled Trial of the Safety of 3% SPL7013 Gel (VivaGel®) in Healthy Young Women Administered Twice Daily for 14 Days
por: Cohen, Craig R., et al.
Publicado: (2011)

Fluticasone furoate: once-daily evening treatment versus twice-daily treatment in moderate asthma
por: Woodcock, Ashley, et al.
Publicado: (2011)

Comparison of once-daily versus twice-daily combination of Ropinirole prolonged release in Parkinson’s disease
por: Yun, Ji Young, et al.
Publicado: (2013)

Effects of Converting Tacrolimus Formulation from Twice-Daily to Once-Daily in Liver Transplantation Recipients
por: Thorat, Ashok, et al.
Publicado: (2014)

Twice-Daily versus Once-Daily Pramipexole Extended Release Dosage Regimens in Parkinson's Disease
por: Yun, Ji Young, et al.
Publicado: (2017)

Twice-daily versus once-daily lisinopril and losartan for hypertension: Real-world effectiveness and safety
por: Derington, Catherine G., et al.
Publicado: (2020)

Efficacy and safety of once daily tacrolimus compared to twice daily tacrolimus after liver transplantation
por: Bzeizi, Khalid Ibrahim, et al.
Publicado: (2021)

A randomized trial of once daily versus twice daily dosing of oral iron in CKD
por: Sood, Vivek, et al.
Publicado: (2023)

RIVAroxaban TWICE daily for lysis of thrombus in the left atrial appendage in patients with non-valvular atrial fibrillation: the RIVA-TWICE study
por: Piotrowski, Roman, et al.
Publicado: (2019)

Development and Preclinical Investigation of Physically Cross-Linked and pH-Sensitive Polymeric Gels as Potential Vaginal Contraceptives
por: Rochani, Ankit, et al.
Publicado: (2022)

Daily oral grepafloxacin vs. twice daily oral doxycycline in the treatment of Chlamydia trachomatis endocervical infection.
por: McCormack, W M, et al.
Publicado: (1998)

Comparison of once-daily versus twice-daily dosing of valsartan in patients with chronic stable heart failure
por: Anand, Inder S, et al.
Publicado: (2010)

Bridging the Gap between Preclinical and Clinical Microbicide Trials: Blind Evaluation of Candidate Gels in Murine Models of Efficacy and Safety
por: Segarra, Theodore J., et al.
Publicado: (2011)

Impact of contraceptive initiation on vaginal microbiota
por: Achilles, Sharon L., et al.
Publicado: (2018)

Metronidazole vaginal gel 0.75% (MetroGel-Vaginal): a brief review.
por: Wain, A M
Publicado: (1998)

The Human Vaginal Bacterial Biota and Bacterial Vaginosis
por: Srinivasan, Sujatha, et al.
Publicado: (2008)

Effectiveness of twice daily azelastine nasal spray in patients with seasonal allergic rhinitis
por: Horak, Friedrich
Publicado: (2008)

Bimodal Solutions or Twice-Daily Icodextrin to Enhance Ultrafiltration in Peritoneal Dialysis Patients
por: Dousdampanis, Periklis, et al.
Publicado: (2013)

Using Exenatide Twice Daily or Insulin in Clinical Practice: Results from CHOICE
por: Mathieu, Chantal, et al.
Publicado: (2013)

Effect of Twice-Daily Blue Light Treatment on Matrix-Rich Biofilm Development
por: Lins de Sousa, Denise, et al.
Publicado: (2015)

Once vs. twice-daily lopinavir/ritonavir in HIV-1-infected children
Publicado: (2015)

Bioequivalence of twice-daily oral tacrolimus in transplant recipients: More evidence for consensus?
por: Ball, Simon
Publicado: (2017)

Twice-daily insulin glargine for patients with uncontrolled type 2 diabetes mellitus
por: Eledrisi, Mohsen, et al.
Publicado: (2018)

Twice daily low frequency rTMS for treatment-resistant auditory hallucinations
por: Brunelin, Jérôme, et al.
Publicado: (2023)

Changes in key vaginal bacteria among postpartum African women initiating intramuscular depot-medroxyprogesterone acetate
por: Whitney, Bridget M., et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_s1984s0sfnf70fidiepieodvjt