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FUS-NLS/Transportin 1 Complex Structure Provides Insights into the Nuclear Targeting Mechanism of FUS and the Implications in ALS

The C-terminal nuclear localization sequence of FUsed in Sarcoma (FUS-NLS) is critical for its nuclear import mediated by transportin (Trn1). Familial amyotrophic lateral sclerosis (ALS) related mutations are clustered in FUS-NLS. We report here the structural, biochemical and cell biological charac...

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Detalles Bibliográficos
Autores principales:	Niu, Chunyan, Zhang, Jiayu, Gao, Feng, Yang, Liuqing, Jia, Minze, Zhu, Haining, Gong, Weimin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466232/ https://www.ncbi.nlm.nih.gov/pubmed/23056579 http://dx.doi.org/10.1371/journal.pone.0047056

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