Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects

Delayed onset muscle soreness (DOMS) is a subacute pain state arising 24–48 hours after a bout of unaccustomed eccentric muscle contractions. Functional magnetic resonance imaging (fMRI) was used to examine the patterns of cortical activation arising during DOMS-related pain in the quadriceps muscle...

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Autores principales: Zimmermann, Katharina, Leidl, Caroline, Kaschka, Miriam, Carr, Richard W., Terekhin, Pavel, Handwerker, Hermann O., Forster, Clemens
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466236/
https://www.ncbi.nlm.nih.gov/pubmed/23056613
http://dx.doi.org/10.1371/journal.pone.0047230
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author Zimmermann, Katharina
Leidl, Caroline
Kaschka, Miriam
Carr, Richard W.
Terekhin, Pavel
Handwerker, Hermann O.
Forster, Clemens
author_facet Zimmermann, Katharina
Leidl, Caroline
Kaschka, Miriam
Carr, Richard W.
Terekhin, Pavel
Handwerker, Hermann O.
Forster, Clemens
author_sort Zimmermann, Katharina
collection PubMed
description Delayed onset muscle soreness (DOMS) is a subacute pain state arising 24–48 hours after a bout of unaccustomed eccentric muscle contractions. Functional magnetic resonance imaging (fMRI) was used to examine the patterns of cortical activation arising during DOMS-related pain in the quadriceps muscle of healthy volunteers evoked by either voluntary contraction or physical stimulation. The painful movement or physical stimulation of the DOMS-affected thigh disclosed widespread activation in the primary somatosensory and motor (S1, M1) cortices, stretching far beyond the corresponding areas somatotopically related to contraction or physical stimulation of the thigh; activation also included a large area within the cingulate cortex encompassing posteroanterior regions and the cingulate motor area. Pain-related activations were also found in premotor (M2) areas, bilateral in the insular cortex and the thalamic nuclei. In contrast, movement of a DOMS-affected limb led also to activation in the ipsilateral anterior cerebellum, while DOMS-related pain evoked by physical stimulation devoid of limb movement did not.
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spelling pubmed-34662362012-10-10 Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects Zimmermann, Katharina Leidl, Caroline Kaschka, Miriam Carr, Richard W. Terekhin, Pavel Handwerker, Hermann O. Forster, Clemens PLoS One Research Article Delayed onset muscle soreness (DOMS) is a subacute pain state arising 24–48 hours after a bout of unaccustomed eccentric muscle contractions. Functional magnetic resonance imaging (fMRI) was used to examine the patterns of cortical activation arising during DOMS-related pain in the quadriceps muscle of healthy volunteers evoked by either voluntary contraction or physical stimulation. The painful movement or physical stimulation of the DOMS-affected thigh disclosed widespread activation in the primary somatosensory and motor (S1, M1) cortices, stretching far beyond the corresponding areas somatotopically related to contraction or physical stimulation of the thigh; activation also included a large area within the cingulate cortex encompassing posteroanterior regions and the cingulate motor area. Pain-related activations were also found in premotor (M2) areas, bilateral in the insular cortex and the thalamic nuclei. In contrast, movement of a DOMS-affected limb led also to activation in the ipsilateral anterior cerebellum, while DOMS-related pain evoked by physical stimulation devoid of limb movement did not. Public Library of Science 2012-10-08 /pmc/articles/PMC3466236/ /pubmed/23056613 http://dx.doi.org/10.1371/journal.pone.0047230 Text en © 2012 Zimmermann et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Zimmermann, Katharina
Leidl, Caroline
Kaschka, Miriam
Carr, Richard W.
Terekhin, Pavel
Handwerker, Hermann O.
Forster, Clemens
Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects
title Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects
title_full Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects
title_fullStr Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects
title_full_unstemmed Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects
title_short Central Projection of Pain Arising from Delayed Onset Muscle Soreness (DOMS) in Human Subjects
title_sort central projection of pain arising from delayed onset muscle soreness (doms) in human subjects
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466236/
https://www.ncbi.nlm.nih.gov/pubmed/23056613
http://dx.doi.org/10.1371/journal.pone.0047230
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