Cargando…

Dimethylfumarate Attenuates Renal Fibrosis via NF-E2-Related Factor 2-Mediated Inhibition of Transforming Growth Factor-β/Smad Signaling

TGF-β plays a key role in the development of renal fibrosis. Suppressing the TGF-β signaling pathway is a possible therapeutic approach for preventing this disease, and reports have suggested that Nrf2 protects against renal fibrosis by inhibiting TGF-β signaling. This study examines whether dimethy...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oh, Chang Joo, Kim, Joon-Young, Choi, Young-Keun, Kim, Han-Jong, Jeong, Ji-Yun, Bae, Kwi-Hyun, Park, Keun-Gyu, Lee, In-Kyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466265/ https://www.ncbi.nlm.nih.gov/pubmed/23056222 http://dx.doi.org/10.1371/journal.pone.0045870

Ejemplares similares

Correction: Dimethylfumarate Attenuates Renal Fibrosis via NF-E2-Related Factor 2-Mediated Inhibition of Transforming Growth Factor-β/Smad Signaling
por: Oh, Chang Joo, et al.
Publicado: (2013)

Dimethylfumarate attenuates restenosis after acute vascular injury by cell-specific and Nrf2-dependent mechanisms
por: Oh, Chang Joo, et al.
Publicado: (2014)

Dimethylfumarate Suppresses Adipogenic Differentiation in 3T3-L1 Preadipocytes through Inhibition of STAT3 Activity
por: Kang, Hyeon-Ji, et al.
Publicado: (2013)

Clusterin Attenuates Hepatic Fibrosis by Inhibiting Hepatic Stellate Cell Activation and Downregulating the Smad3 Signaling Pathway
por: Seo, Hye-Young, et al.
Publicado: (2019)

Transcriptional Regulation of Fibroblast Growth Factor 21 Expression
por: Bae, Kwi-Hyun, et al.
Publicado: (2014)

The Effects of Retinoic Acid and MAPK Inhibitors on Phosphorylation of Smad2/3 Induced by Transforming Growth Factor β1
por: Lee, Sang Hoon, et al.
Publicado: (2019)

Anti-Inflammatory Dimethylfumarate: A Potential New Therapy for Asthma?
por: Seidel, Petra, et al.
Publicado: (2013)

Lobeglitazone, a Novel Peroxisome Proliferator-Activated Receptor γ Agonist, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
por: Bae, Kwi-Hyun, et al.
Publicado: (2017)

MicroRNA-21 inhibition attenuates airway inflammation and remodelling by modulating the transforming growth factor β–Smad7 pathway
por: Hur, Jung, et al.
Publicado: (2021)

Kahweol decreases hepatic fibrosis by inhibiting the expression of connective tissue growth factor via the transforming growth factor-beta signaling pathway
por: Seo, Hye-Young, et al.
Publicado: (2017)

Depletion of Saccharomyces cerevisiae in psoriasis patients, restored by Dimethylfumarate therapy (DMF)
por: Eppinga, Hester, et al.
Publicado: (2017)

Acetazolamide attenuates cardiac fibrosis induced by aortic constriction through inhibiting transforming growth factor-β1/Smad2 signaling pathway in mice
por: Huo, Qianqian, et al.
Publicado: (2019)

Increased biomass and lipid production by continuous cultivation of Nannochloropsis salina transformant overexpressing a bHLH transcription factor
por: Kang, Nam Kyu, et al.
Publicado: (2019)

Inhibition of p300/CBP-Associated Factor Attenuates Renal Tubulointerstitial Fibrosis through Modulation of NF-kB and Nrf2
por: Chung, Sungjin, et al.
Publicado: (2019)

Switching from a fumaric acid ester mixture to dimethylfumarate monotherapy in psoriasis
por: Warren, R.B., et al.
Publicado: (2019)

Src Inhibition Attenuates Liver Fibrosis by Preventing Hepatic Stellate Cell Activation and Decreasing Connective Tissue Growth Factor
por: Seo, Hye-Young, et al.
Publicado: (2020)

Inhibitory Effects of Resveratrol on Airway Remodeling by Transforming Growth Factor-β/Smad Signaling Pathway in Chronic Asthma Model
por: Lee, Hwa Young, et al.
Publicado: (2017)

Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation
por: Lee, Sun Joo, et al.
Publicado: (2015)

Corrigendum: Pyruvate Dehydrogenase Kinase 4 Promotes Vascular Calcification via SMAD1/5/8 Phosphorylation
por: Lee, Sun Joo, et al.
Publicado: (2016)

Evogliptin, a Dipeptidyl Peptidase-4 Inhibitor, Attenuates Renal Fibrosis Caused by Unilateral Ureteral Obstruction in Mice
por: Kim, Mi-Jin, et al.
Publicado: (2020)

Clusterin/Apolipoprotein J Attenuates Angiotensin II-Induced Renal Fibrosis
por: Jung, Gwon-Soo, et al.
Publicado: (2014)

Specific Inhibitor of Smad3 (SIS3) Attenuates Fibrosis, Apoptosis, and Inflammation in Unilateral Ureteral Obstruction Kidneys by Inhibition of Transforming Growth Factor β (TGF-β)/Smad3 Signaling
por: Ji, Xingli, et al.
Publicado: (2018)

Dimethylfumarate protects against TNF-α-induced secretion of inflammatory cytokines in human endothelial cells
por: Gerhardt, Simon, et al.
Publicado: (2015)

Dimethylfumarate Inhibits Colorectal Carcinoma Cell Proliferation: Evidence for Cell Cycle Arrest, Apoptosis and Autophagy
por: Kaluzki, Irina, et al.
Publicado: (2019)

Autophagy attenuates tubulointerstital fibrosis through regulating transforming growth factor-β and NLRP3 inflammasome signaling pathway
por: Nam, Sun Ah, et al.
Publicado: (2019)

Clinical Characteristics for 348 Patients with Adrenal Incidentaloma
por: Kim, Jongho, et al.
Publicado: (2013)

Dab2 attenuates brain injury in APP/PS1 mice via targeting transforming growth factor-beta/SMAD signaling
por: Song, Lei, et al.
Publicado: (2014)

Transforming Growth Factor β Inhibits MUC5AC Expression by Smad3/HDAC2 Complex Formation and NF-κB Deacetylation at K310 in NCI-H292 Cells
por: Lee, Su Ui, et al.
Publicado: (2021)

Suaeda glauca Attenuates Liver Fibrosis in Mice by Inhibiting TGFβ1-Smad2/3 Signaling in Hepatic Stellate Cells
por: Hong, You-Jung, et al.
Publicado: (2023)

Prohaptoglobin inhibits the transforming growth factor-β-induced epithelial-to-mesenchymal transition in vitro by increasing Smad1/5 activation and suppressing the Smad2/3 signaling pathway in SK-Hep1 liver cancer cells
por: Oh, Mi-Kyung, et al.
Publicado: (2022)

The expression dynamics of transforming growth factor-β/Smad signaling in the liver fibrosis experimentally caused by Clonorchis sinensis
por: Yan, Chao, et al.
Publicado: (2015)

Piperine ameliorates the severity of fibrosis via inhibition of TGF-β/SMAD signaling in a mouse model of chronic pancreatitis
por: Choi, Ji-Won, et al.
Publicado: (2019)

MicroRNA‐411‐3p inhibits bleomycin‐induced skin fibrosis by regulating transforming growth factor‐β/Smad ubiquitin regulatory factor‐2 signalling
por: Zhang, Ziyan, et al.
Publicado: (2021)

CR6-interacting Factor 1 (CRIF1) Regulates NF-E2-related Factor 2 (NRF2) Protein Stability by Proteasome-mediated Degradation
por: Kang, Hyo Jin, et al.
Publicado: (2010)

Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis
por: Kim, Kwangho, et al.
Publicado: (2023)

Expression and localization of the transforming growth factor-beta type I receptor and Smads in preneoplastic lesions during chemical hepatocarcinogenesis in rats.
por: Park, Do Youn, et al.
Publicado: (2003)

Rhus verniciflua Stokes attenuates cholestatic liver cirrhosis-induced interstitial fibrosis via Smad3 down-regulation and Smad7 up-regulation
por: Gil, Mi Na, et al.
Publicado: (2016)

Involvement of epithelial-to-mesenchymal transition and associated transforming growth factor-β/Smad signaling in paraquat-induced pulmonary fibrosis
por: HAN, YING-YING, et al.
Publicado: (2015)

Therapeutic Effects of an Inhibitor of Thioredoxin Reductase on Liver Fibrosis by Inhibiting the Transforming Growth Factor-β1/Smads Pathway
por: Jiao, Wenxuan, et al.
Publicado: (2021)

2-Arachidonoylglycerol Attenuates Myocardial Fibrosis in Diabetic Mice Via the TGF-β1/Smad Pathway
por: Chen, Zhengjie, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_u6f04iub7vi3hnlkcm7920h5s5