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A Comprehensive Strategy to Discover Inhibitors of the Translesion Synthesis DNA Polymerase κ

Human DNA polymerase kappa (pol κ) is a translesion synthesis (TLS) polymerase that catalyzes TLS past various minor groove lesions including N (2)-dG linked acrolein- and polycyclic aromatic hydrocarbon-derived adducts, as well as N (2)-dG DNA–DNA interstrand cross-links introduced by the chemother...

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Detalles Bibliográficos
Autores principales:	Yamanaka, Kinrin, Dorjsuren, Dorjbal, Eoff, Robert L., Egli, Martin, Maloney, David J., Jadhav, Ajit, Simeonov, Anton, Lloyd, R. Stephen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466269/ https://www.ncbi.nlm.nih.gov/pubmed/23056190 http://dx.doi.org/10.1371/journal.pone.0045032

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