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Conjugation of Proteins by Installing BIO-Orthogonally Reactive Groups at Their N-Termini

N-terminal site-specific modification of a protein has many advantages over methods targeting internal positions, but it is not easy to install reactive groups onto a protein in an N-terminal specific manner. We here report a strategy to incorporate amino acid analogues specifically in the N-terminu...

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Detalles Bibliográficos
Autores principales: Soundrarajan, Nagasundarapandian, Sokalingam, Sriram, Raghunathan, Govindan, Budisa, Nediljko, Paik, Hyun-Jong, Yoo, Tae Hyeon, Lee, Sun-Gu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466299/
https://www.ncbi.nlm.nih.gov/pubmed/23056430
http://dx.doi.org/10.1371/journal.pone.0046741