Evolutionary Conserved Role of c-Jun-N-Terminal Kinase in CO(2)-Induced Epithelial Dysfunction

Elevated CO(2) levels (hypercapnia) occur in patients with respiratory diseases and impair alveolar epithelial integrity, in part, by inhibiting Na,K-ATPase function. Here, we examined the role of c-Jun N-terminal kinase (JNK) in CO(2) signaling in mammalian alveolar epithelial cells as well as in d...

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Detalles Bibliográficos
Autores principales: Vadász, István, Dada, Laura A., Briva, Arturo, Helenius, Iiro Taneli, Sharabi, Kfir, Welch, Lynn C., Kelly, Aileen M., Grzesik, Benno A., Budinger, G. R. Scott, Liu, Jing, Seeger, Werner, Beitel, Greg J., Gruenbaum, Yosef, Sznajder, Jacob I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2012
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466313/
https://www.ncbi.nlm.nih.gov/pubmed/23056407
http://dx.doi.org/10.1371/journal.pone.0046696

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