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IL-1 family cytokines trigger sterile inflammatory disease
Inflammation plays vital roles in protective responses against pathogens and tissue repair, however, improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2012
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466588/ https://www.ncbi.nlm.nih.gov/pubmed/23087690 http://dx.doi.org/10.3389/fimmu.2012.00315 |
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author | Lukens, John R. Gross, Jordan M. Kanneganti, Thirumala-Devi |
author_facet | Lukens, John R. Gross, Jordan M. Kanneganti, Thirumala-Devi |
author_sort | Lukens, John R. |
collection | PubMed |
description | Inflammation plays vital roles in protective responses against pathogens and tissue repair, however, improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory processes that are required for pathogen clearance, however, in comparison, less is known about the regulation of inflammation in sterile settings. Over the past decade non-communicable chronic diseases that are potentiated by sterile inflammation have replaced infectious diseases as the major threat to global human health. Thus, improved understanding of the sterile inflammatory process has emerged as one of the most important areas of biomedical investigation during our time. In this review we highlight the central role that interleukin-1 family cytokines play in sterile inflammatory diseases. |
format | Online Article Text |
id | pubmed-3466588 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-34665882012-10-19 IL-1 family cytokines trigger sterile inflammatory disease Lukens, John R. Gross, Jordan M. Kanneganti, Thirumala-Devi Front Immunol Immunology Inflammation plays vital roles in protective responses against pathogens and tissue repair, however, improper resolution of inflammatory networks is centrally involved in the pathogenesis of many acute and chronic diseases. Extensive advances have been made in recent years to define the inflammatory processes that are required for pathogen clearance, however, in comparison, less is known about the regulation of inflammation in sterile settings. Over the past decade non-communicable chronic diseases that are potentiated by sterile inflammation have replaced infectious diseases as the major threat to global human health. Thus, improved understanding of the sterile inflammatory process has emerged as one of the most important areas of biomedical investigation during our time. In this review we highlight the central role that interleukin-1 family cytokines play in sterile inflammatory diseases. Frontiers Media S.A. 2012-10-09 /pmc/articles/PMC3466588/ /pubmed/23087690 http://dx.doi.org/10.3389/fimmu.2012.00315 Text en Copyright © Lukens, Gross and Kanneganti. http://www.frontiersin.org/licenseagreement This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) , which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and subject to any copyright notices concerning any third-party graphics etc. |
spellingShingle | Immunology Lukens, John R. Gross, Jordan M. Kanneganti, Thirumala-Devi IL-1 family cytokines trigger sterile inflammatory disease |
title | IL-1 family cytokines trigger sterile inflammatory disease |
title_full | IL-1 family cytokines trigger sterile inflammatory disease |
title_fullStr | IL-1 family cytokines trigger sterile inflammatory disease |
title_full_unstemmed | IL-1 family cytokines trigger sterile inflammatory disease |
title_short | IL-1 family cytokines trigger sterile inflammatory disease |
title_sort | il-1 family cytokines trigger sterile inflammatory disease |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3466588/ https://www.ncbi.nlm.nih.gov/pubmed/23087690 http://dx.doi.org/10.3389/fimmu.2012.00315 |
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