Crucial role of dynamic linker histone binding and divalent ions for DNA accessibility and gene regulation revealed by mesoscale modeling of oligonucleosomes

Monte Carlo simulations of a mesoscale model of oligonucleosomes are analyzed to examine the role of dynamic-linker histone (LH) binding/unbinding in high monovalent salt with divalent ions, and to further interpret noted chromatin fiber softening by dynamic LH in monovalent salt conditions. We find...

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Detalles Bibliográficos
Autores principales: Collepardo-Guevara, Rosana, Schlick, Tamar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Computational Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467040/
https://www.ncbi.nlm.nih.gov/pubmed/22790986
http://dx.doi.org/10.1093/nar/gks600

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467040/
https://www.ncbi.nlm.nih.gov/pubmed/22790986
http://dx.doi.org/10.1093/nar/gks600

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