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Preferred WMSA catalytic mechanism of the nucleotidyl transfer reaction in human DNA polymerase κ elucidates error-free bypass of a bulky DNA lesion

Human DNA Pol κ is a polymerase enzyme, specialized for near error-free bypass of certain bulky chemical lesions to DNA that are derived from environmental carcinogens present in tobacco smoke, automobile exhaust and cooked food. By employing ab initio QM/MM–MD (Quantum Mechanics/Molecular Mechanics...

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Detalles Bibliográficos
Autores principales:	Lior-Hoffmann, Lee, Wang, Lihua, Wang, Shenglong, Geacintov, Nicholas E., Broyde, Suse, Zhang, Yingkai
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467051/ https://www.ncbi.nlm.nih.gov/pubmed/22772988 http://dx.doi.org/10.1093/nar/gks653

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