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Lesion-specific DNA-binding and repair activities of human O(6)-alkylguanine DNA alkyltransferase

Binding experiments with alkyl-transfer-active and -inactive mutants of human O(6)-alkylguanine DNA alkyltransferase (AGT) show that it forms an O(6)-methylguanine (6mG)-specific complex on duplex DNA that is distinct from non-specific assemblies previously studied. Specific complexes with duplex DN...

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Detalles Bibliográficos
Autores principales:	Melikishvili, Manana, Fried, Michael G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Genome Integrity, Repair and Replication
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467069/ https://www.ncbi.nlm.nih.gov/pubmed/22810209 http://dx.doi.org/10.1093/nar/gks674

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