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Efficient deamination of 5-methylcytosines in DNA by human APOBEC3A, but not by AID or APOBEC3G

The AID/APOBEC family of enzymes in higher vertebrates converts cytosines in DNA or RNA to uracil. They play a role in antibody maturation and innate immunity against viruses, and have also been implicated in the demethylation of DNA during early embryogenesis. This is based in part on reported abil...

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Detalles Bibliográficos
Autores principales:	Wijesinghe, Priyanga, Bhagwat, Ashok S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2012
Materias:	Nucleic Acid Enzymes
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467078/ https://www.ncbi.nlm.nih.gov/pubmed/22798497 http://dx.doi.org/10.1093/nar/gks685

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