Residues of E. coli topoisomerase I conserved for interaction with a specific cytosine base to facilitate DNA cleavage

Bacterial and archaeal topoisomerase I display selectivity for a cytosine base 4 nt upstream from the DNA cleavage site. Recently, the solved crystal structure of Escherichia coli topoisomerase I covalently linked to a single-stranded oligonucleotide revealed that R169 and R173 interact with the cyt...

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Detalles Bibliográficos
Autores principales: Narula, Gagandeep, Tse-Dinh, Yuk-Ching
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2012
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467081/
https://www.ncbi.nlm.nih.gov/pubmed/22833607
http://dx.doi.org/10.1093/nar/gks688

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467081/
https://www.ncbi.nlm.nih.gov/pubmed/22833607
http://dx.doi.org/10.1093/nar/gks688

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