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The I2020T Leucine-rich repeat kinase 2 transgenic mouse exhibits impaired locomotive ability accompanied by dopaminergic neuron abnormalities

BACKGROUND: Leucine-rich repeat kinase 2 (LRRK2) is the gene responsible for autosomal-dominant Parkinson’s disease (PD), PARK8, but the mechanism by which LRRK2 mutations cause neuronal dysfunction remains unknown. In the present study, we investigated for the first time a transgenic (TG) mouse str...

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Detalles Bibliográficos
Autores principales:	Maekawa, Tatsunori, Mori, Sayuri, Sasaki, Yui, Miyajima, Takashi, Azuma, Sadahiro, Ohta, Etsuro, Obata, Fumiya
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467184/ https://www.ncbi.nlm.nih.gov/pubmed/22534020 http://dx.doi.org/10.1186/1750-1326-7-15

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