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Transcriptional Activation and Cell Cycle Block Are the Keys for 5-Fluorouracil Induced Up-Regulation of Human Thymidylate Synthase Expression

BACKGROUND: 5-fluorouracil, a commonly used chemotherapeutic agent, up-regulates expression of human thymidylate synthase (hTS). Several different regulatory mechanisms have been proposed to mediate this up-regulation in distinct cell lines, but their specific contributions in a single cell line hav...

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Detalles Bibliográficos
Autores principales:	Ligabue, Alessio, Marverti, Gaetano, Liebl, Ursula, Myllykallio, Hannu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467224/ https://www.ncbi.nlm.nih.gov/pubmed/23056627 http://dx.doi.org/10.1371/journal.pone.0047318

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