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Pax6 Directly Down-Regulates Pcsk1n Expression Thereby Regulating PC1/3 Dependent Proinsulin Processing

BACKGROUND: Heterozygous paired box6 (Pax6) mutations lead to abnormal glucose metabolism in mice older than 6 months as well as in human beings. Our previous study found that Pax6 deficiency caused down-expression of prohormone convertase 1/3 (Pcsk1), resulting in defective proinsulin processing. A...

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Detalles Bibliográficos
Autores principales:	Liu, Ting, Zhao, Yanxia, Tang, Na, Feng, Ruopeng, Yang, Xiaolong, Lu, Nicole, Wen, Jinhua, Li, Lingsong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2012
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467282/ https://www.ncbi.nlm.nih.gov/pubmed/23056534 http://dx.doi.org/10.1371/journal.pone.0046934

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