The Past, Present, and Future of Adoptive T Cell Therapy

Although adoptive T cell therapy (ACT) has become a promising immunotherapeutic regime for cancer treatment, its effectiveness has been hindered by several inherent shortcomings regarding safety and efficacy. During the past few decades, several strategies for enhancing the efficacy of ACT have been...

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Detalles Bibliográficos
Autores principales: Choi, Donghoon, Kim, Tai-Gyu, Sung, Young Chul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Association of Immunologists 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467412/
https://www.ncbi.nlm.nih.gov/pubmed/23091437
http://dx.doi.org/10.4110/in.2012.12.4.139
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author Choi, Donghoon
Kim, Tai-Gyu
Sung, Young Chul
author_facet Choi, Donghoon
Kim, Tai-Gyu
Sung, Young Chul
author_sort Choi, Donghoon
collection PubMed
description Although adoptive T cell therapy (ACT) has become a promising immunotherapeutic regime for cancer treatment, its effectiveness has been hindered by several inherent shortcomings regarding safety and efficacy. During the past few decades, several strategies for enhancing the efficacy of ACT have been developed and introduced in clinic. This review will summarize not only the past approaches but also the latest strategies which have been shown to enhance the anticancer activity of ACT.
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spelling pubmed-34674122012-10-22 The Past, Present, and Future of Adoptive T Cell Therapy Choi, Donghoon Kim, Tai-Gyu Sung, Young Chul Immune Netw Review Article Although adoptive T cell therapy (ACT) has become a promising immunotherapeutic regime for cancer treatment, its effectiveness has been hindered by several inherent shortcomings regarding safety and efficacy. During the past few decades, several strategies for enhancing the efficacy of ACT have been developed and introduced in clinic. This review will summarize not only the past approaches but also the latest strategies which have been shown to enhance the anticancer activity of ACT. The Korean Association of Immunologists 2012-08 2012-08-31 /pmc/articles/PMC3467412/ /pubmed/23091437 http://dx.doi.org/10.4110/in.2012.12.4.139 Text en Copyright © 2012 The Korean Association of Immunologists http://creativecommons.org/licenses/by-nc/3.0 This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Choi, Donghoon
Kim, Tai-Gyu
Sung, Young Chul
The Past, Present, and Future of Adoptive T Cell Therapy
title The Past, Present, and Future of Adoptive T Cell Therapy
title_full The Past, Present, and Future of Adoptive T Cell Therapy
title_fullStr The Past, Present, and Future of Adoptive T Cell Therapy
title_full_unstemmed The Past, Present, and Future of Adoptive T Cell Therapy
title_short The Past, Present, and Future of Adoptive T Cell Therapy
title_sort past, present, and future of adoptive t cell therapy
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467412/
https://www.ncbi.nlm.nih.gov/pubmed/23091437
http://dx.doi.org/10.4110/in.2012.12.4.139
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