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Affinity Maturation of an Epidermal Growth Factor Receptor Targeting Human Monoclonal Antibody ER414 by CDR Mutation

It is well established that blocking the interaction of EGFR with growth factors leads to the arrest of tumor growth, resulting in tumor cell death. ER414 is a human monoclonal antibody (mAb) derived by guided selection of the mouse mAb A13. The ER414 exhibited a ~17-fold lower affinity and, as a re...

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Detalles Bibliográficos
Autores principales:	Chang, Ki-Hwan, Kim, Min-Soo, Hong, Gwang-Won, Seo, Mi-Sun, Shin, Yong-Nam, Kim, Se-Ho
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Korean Association of Immunologists 2012
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467414/ https://www.ncbi.nlm.nih.gov/pubmed/23091439 http://dx.doi.org/10.4110/in.2012.12.4.155

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