Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer

Among all types of cancer, incidence of lung cancer remains the highest with regard to cancer-related mortality. Problems contributing to recurrence of the disease include metastasis and drug resistance. Mounting evidence has demonstrated involvement of epithelial mesenchymal transition (EMT) in can...

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Detalles Bibliográficos
Autores principales: Nurwidya, Fariz, Takahashi, Fumiyuki, Murakami, Akiko, Takahashi, Kazuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467417/
https://www.ncbi.nlm.nih.gov/pubmed/23091440
http://dx.doi.org/10.4143/crt.2012.44.3.151
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author Nurwidya, Fariz
Takahashi, Fumiyuki
Murakami, Akiko
Takahashi, Kazuhisa
author_facet Nurwidya, Fariz
Takahashi, Fumiyuki
Murakami, Akiko
Takahashi, Kazuhisa
author_sort Nurwidya, Fariz
collection PubMed
description Among all types of cancer, incidence of lung cancer remains the highest with regard to cancer-related mortality. Problems contributing to recurrence of the disease include metastasis and drug resistance. Mounting evidence has demonstrated involvement of epithelial mesenchymal transition (EMT) in cancer progression. EMT is a critical mechanism ensuring tissue remodeling during morphogenesis of multicellular organisms. Therefore, understanding of the biology of this process for identification of potential EMT-targeted therapeutic strategies for the benefit cancer patients is necessary. This review describes recent evidence of EMT involvement in drug resistance and metastasis of cancers, with an emphasis on lung cancer.
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spelling pubmed-34674172012-10-22 Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer Nurwidya, Fariz Takahashi, Fumiyuki Murakami, Akiko Takahashi, Kazuhisa Cancer Res Treat Review Article Among all types of cancer, incidence of lung cancer remains the highest with regard to cancer-related mortality. Problems contributing to recurrence of the disease include metastasis and drug resistance. Mounting evidence has demonstrated involvement of epithelial mesenchymal transition (EMT) in cancer progression. EMT is a critical mechanism ensuring tissue remodeling during morphogenesis of multicellular organisms. Therefore, understanding of the biology of this process for identification of potential EMT-targeted therapeutic strategies for the benefit cancer patients is necessary. This review describes recent evidence of EMT involvement in drug resistance and metastasis of cancers, with an emphasis on lung cancer. Korean Cancer Association 2012-09 2012-09-30 /pmc/articles/PMC3467417/ /pubmed/23091440 http://dx.doi.org/10.4143/crt.2012.44.3.151 Text en Copyright © 2012 by the Korean Cancer Association http://creativecommons.org/licenses/by-nc/3.0 This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Nurwidya, Fariz
Takahashi, Fumiyuki
Murakami, Akiko
Takahashi, Kazuhisa
Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer
title Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer
title_full Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer
title_fullStr Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer
title_full_unstemmed Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer
title_short Epithelial Mesenchymal Transition in Drug Resistance and Metastasis of Lung Cancer
title_sort epithelial mesenchymal transition in drug resistance and metastasis of lung cancer
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467417/
https://www.ncbi.nlm.nih.gov/pubmed/23091440
http://dx.doi.org/10.4143/crt.2012.44.3.151
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