Cargando…

Computational model of neuron-astrocyte interactions during focal seizure generation

Empirical research in the last decade revealed that astrocytes can respond to neurotransmitters with Ca(2+) elevations and generate feedback signals to neurons which modulate synaptic transmission and neuronal excitability. This discovery changed our basic understanding of brain function and provide...

Descripción completa

Detalles Bibliográficos
Autores principales:	Reato, Davide, Cammarota, Mario, Parra, Lucas C., Carmignoto, Giorgio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2012
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467689/ https://www.ncbi.nlm.nih.gov/pubmed/23091457 http://dx.doi.org/10.3389/fncom.2012.00081

Ejemplares similares

An Excitatory Loop with Astrocytes Contributes to Drive Neurons to Seizure Threshold
por: Gómez-Gonzalo, Marta, et al.
Publicado: (2010)

The inflammatory molecules IL-1β and HMGB1 can rapidly enhance focal seizure generation in a brain slice model of temporal lobe epilepsy
por: Chiavegato, Angela, et al.
Publicado: (2014)

Computational models of neuron-astrocyte interaction in epilepsy
por: Volman, Vladislav, et al.
Publicado: (2012)

A brain slice experimental model to study the generation and the propagation of focally-induced epileptiform activity
por: Losi, Gabriele, et al.
Publicado: (2016)

New Tools to Study Astrocyte Ca(2+) Signal Dynamics in Brain Networks In Vivo
por: Losi, Gabriele, et al.
Publicado: (2017)

A Computational Model of Interactions Between Neuronal and Astrocytic Networks: The Role of Astrocytes in the Stability of the Neuronal Firing Rate
por: Lenk, Kerstin, et al.
Publicado: (2020)

Effects of weak transcranial alternating current stimulation on brain activity—a review of known mechanisms from animal studies
por: Reato, Davide, et al.
Publicado: (2013)

Calcium Signals in Astrocyte Microdomains, a Decade of Great Advances
por: Lia, Annamaria, et al.
Publicado: (2021)

Long-term effects of weak electrical stimulation on active neuronal networks
por: Reato, Davide, et al.
Publicado: (2013)

The Role of Astroglia in the Epileptic Brain
por: Losi, Gabriele, et al.
Publicado: (2012)

Ictal but Not Interictal Epileptic Discharges Activate Astrocyte Endfeet and Elicit Cerebral Arteriole Responses
por: Gómez-Gonzalo, Marta, et al.
Publicado: (2011)

Novel astrocyte targets: New Avenues for the Therapeutic Treatment of Epilepsy
por: Crunelli, Vincenzo, et al.
Publicado: (2015)

Computational modelling of micro-seizures and focal seizure onset
por: Wang, Yujiang, et al.
Publicado: (2013)

Biophysically based computational models of astrocyte ~ neuron coupling and their functional significance
por: Wade, John, et al.
Publicado: (2013)

Mitochondrial Dysfunction in Astrocytes Impairs the Generation of Reactive Astrocytes and Enhances Neuronal Cell Death in the Cortex Upon Photothrombotic Lesion
por: Fiebig, Christian, et al.
Publicado: (2019)

Astrocyte-Neuron Interactions during Learning May Occur by Lactate Signaling Rather than Metabolism
por: DiNuzzo, Mauro
Publicado: (2016)

The Role of Astrocytes in the Generation, Migration, and Integration of New Neurons in the Adult Olfactory Bulb
por: Gengatharan, Archana, et al.
Publicado: (2016)

Metabolic Changes Following Perinatal Asphyxia: Role of Astrocytes and Their Interaction with Neurons
por: Logica, Tamara, et al.
Publicado: (2016)

Neuronal and Astrocytic Regulations in Schizophrenia: A Computational Modelling Study
por: Fritschi, Lea, et al.
Publicado: (2021)

Astrocytes Modulate Somatostatin Interneuron Signaling in the Visual Cortex
por: Henriques, Vanessa Jorge, et al.
Publicado: (2022)

Astrocyte and Neuronal Pannexin1 Contribute Distinctly to Seizures
por: Scemes, Eliana, et al.
Publicado: (2019)

Astrocytic Actions on Extrasynaptic Neuronal Currents
por: Pál, Balázs
Publicado: (2015)

Impaired Baroreflex Sensitivity after Bilateral Convulsive Seizures in Patients with Focal Epilepsy
por: Hampel, Kevin G., et al.
Publicado: (2017)

A Computational Model to Investigate Astrocytic Glutamate Uptake Influence on Synaptic Transmission and Neuronal Spiking
por: Allam, Sushmita L., et al.
Publicado: (2012)

Generating Brain Waves, the Power of Astrocytes
por: Buskila, Yossi, et al.
Publicado: (2019)

Phase-Amplitude Coupling Is Elevated in Deep Sleep and in the Onset Zone of Focal Epileptic Seizures
por: Amiri, Mina, et al.
Publicado: (2016)

AFF2 Is Associated With X-Linked Partial (Focal) Epilepsy With Antecedent Febrile Seizures
por: Zou, Dongfang, et al.
Publicado: (2022)

New tools for investigating astrocyte-to-neuron communication
por: Li, Dongdong, et al.
Publicado: (2013)

The inhibitory neurotransmitter GABA evokes long‐lasting Ca(2+) oscillations in cortical astrocytes
por: Mariotti, Letizia, et al.
Publicado: (2015)

Response outcome gates the effect of spontaneous cortical state fluctuations on perceptual decisions
por: Reato, Davide, et al.
Publicado: (2023)

Astrocytic and Neuronal Apolipoprotein E Isoforms Differentially Affect Neuronal Excitability
por: Konings, Sabine C., et al.
Publicado: (2021)

Hippocampal and Cortical Pyramidal Neurons Swell in Parallel with Astrocytes during Acute Hypoosmolar Stress
por: Murphy, Thomas R., et al.
Publicado: (2017)

Neuron-astrocyte interaction enhance GABAergic synaptic transmission in a manner dependent on key metabolic enzymes
por: Kaczor, Przemysław, et al.
Publicado: (2015)

DEPDC5 Variants Associated Malformations of Cortical Development and Focal Epilepsy With Febrile Seizure Plus/Febrile Seizures: The Role of Molecular Sub-Regional Effect
por: Liu, Liu, et al.
Publicado: (2020)

Multifunctional role of astrocytes as gatekeepers of neuronal energy supply
por: Stobart, Jillian L., et al.
Publicado: (2013)

Functional changes in glutamate transporters and astrocyte biophysical properties in a rodent model of focal cortical dysplasia
por: Campbell, Susan L., et al.
Publicado: (2014)

The piriform, perirhinal, and entorhinal cortex in seizure generation
por: Vismer, Marta S., et al.
Publicado: (2015)

The computational power of astrocyte mediated synaptic plasticity
por: Min, Rogier, et al.
Publicado: (2012)

Computational Models for Calcium-Mediated Astrocyte Functions
por: Manninen, Tiina, et al.
Publicado: (2018)

Ammonia triggers neuronal disinhibition and seizures by impairing astrocyte potassium buffering
por: Thrane, Vinita Rangroo, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_tt32n9jo8o0cfomu33qj49jho8