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Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells

Meissner corpuscles and Merkel cell neurite complexes are highly specialized mechanoreceptors present in the hairy and glabrous skin, as well as in different types of mucosa. Several reports suggest that after injury, such as after nerve crush, freeze injury, or dissection of the nerve, they are abl...

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Autores principales: Widera, Darius, Hauser, Stefan, Kaltschmidt, Christian, Kaltschmidt, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467754/
https://www.ncbi.nlm.nih.gov/pubmed/23082250
http://dx.doi.org/10.1155/2012/837626
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author Widera, Darius
Hauser, Stefan
Kaltschmidt, Christian
Kaltschmidt, Barbara
author_facet Widera, Darius
Hauser, Stefan
Kaltschmidt, Christian
Kaltschmidt, Barbara
author_sort Widera, Darius
collection PubMed
description Meissner corpuscles and Merkel cell neurite complexes are highly specialized mechanoreceptors present in the hairy and glabrous skin, as well as in different types of mucosa. Several reports suggest that after injury, such as after nerve crush, freeze injury, or dissection of the nerve, they are able to regenerate, particularly including reinnervation and repopulation of the mechanoreceptors by Schwann cells. However, little is known about mammalian cells responsible for these regenerative processes. Here we review cellular origin of this plasticity in the light of newly described adult neural crest-derived stem cell populations. We also discuss further potential multipotent stem cell populations with the ability to regenerate disrupted innervation and to functionally recover the mechanoreceptors. These capabilities are discussed as in context to cellularly reprogrammed Schwann cells and tissue resident adult mesenchymal stem cells.
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spelling pubmed-34677542012-10-18 Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells Widera, Darius Hauser, Stefan Kaltschmidt, Christian Kaltschmidt, Barbara Anat Res Int Review Article Meissner corpuscles and Merkel cell neurite complexes are highly specialized mechanoreceptors present in the hairy and glabrous skin, as well as in different types of mucosa. Several reports suggest that after injury, such as after nerve crush, freeze injury, or dissection of the nerve, they are able to regenerate, particularly including reinnervation and repopulation of the mechanoreceptors by Schwann cells. However, little is known about mammalian cells responsible for these regenerative processes. Here we review cellular origin of this plasticity in the light of newly described adult neural crest-derived stem cell populations. We also discuss further potential multipotent stem cell populations with the ability to regenerate disrupted innervation and to functionally recover the mechanoreceptors. These capabilities are discussed as in context to cellularly reprogrammed Schwann cells and tissue resident adult mesenchymal stem cells. Hindawi Publishing Corporation 2012 2012-10-02 /pmc/articles/PMC3467754/ /pubmed/23082250 http://dx.doi.org/10.1155/2012/837626 Text en Copyright © 2012 Darius Widera et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Widera, Darius
Hauser, Stefan
Kaltschmidt, Christian
Kaltschmidt, Barbara
Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells
title Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells
title_full Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells
title_fullStr Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells
title_full_unstemmed Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells
title_short Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells
title_sort origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467754/
https://www.ncbi.nlm.nih.gov/pubmed/23082250
http://dx.doi.org/10.1155/2012/837626
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