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Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells
Meissner corpuscles and Merkel cell neurite complexes are highly specialized mechanoreceptors present in the hairy and glabrous skin, as well as in different types of mucosa. Several reports suggest that after injury, such as after nerve crush, freeze injury, or dissection of the nerve, they are abl...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467754/ https://www.ncbi.nlm.nih.gov/pubmed/23082250 http://dx.doi.org/10.1155/2012/837626 |
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author | Widera, Darius Hauser, Stefan Kaltschmidt, Christian Kaltschmidt, Barbara |
author_facet | Widera, Darius Hauser, Stefan Kaltschmidt, Christian Kaltschmidt, Barbara |
author_sort | Widera, Darius |
collection | PubMed |
description | Meissner corpuscles and Merkel cell neurite complexes are highly specialized mechanoreceptors present in the hairy and glabrous skin, as well as in different types of mucosa. Several reports suggest that after injury, such as after nerve crush, freeze injury, or dissection of the nerve, they are able to regenerate, particularly including reinnervation and repopulation of the mechanoreceptors by Schwann cells. However, little is known about mammalian cells responsible for these regenerative processes. Here we review cellular origin of this plasticity in the light of newly described adult neural crest-derived stem cell populations. We also discuss further potential multipotent stem cell populations with the ability to regenerate disrupted innervation and to functionally recover the mechanoreceptors. These capabilities are discussed as in context to cellularly reprogrammed Schwann cells and tissue resident adult mesenchymal stem cells. |
format | Online Article Text |
id | pubmed-3467754 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34677542012-10-18 Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells Widera, Darius Hauser, Stefan Kaltschmidt, Christian Kaltschmidt, Barbara Anat Res Int Review Article Meissner corpuscles and Merkel cell neurite complexes are highly specialized mechanoreceptors present in the hairy and glabrous skin, as well as in different types of mucosa. Several reports suggest that after injury, such as after nerve crush, freeze injury, or dissection of the nerve, they are able to regenerate, particularly including reinnervation and repopulation of the mechanoreceptors by Schwann cells. However, little is known about mammalian cells responsible for these regenerative processes. Here we review cellular origin of this plasticity in the light of newly described adult neural crest-derived stem cell populations. We also discuss further potential multipotent stem cell populations with the ability to regenerate disrupted innervation and to functionally recover the mechanoreceptors. These capabilities are discussed as in context to cellularly reprogrammed Schwann cells and tissue resident adult mesenchymal stem cells. Hindawi Publishing Corporation 2012 2012-10-02 /pmc/articles/PMC3467754/ /pubmed/23082250 http://dx.doi.org/10.1155/2012/837626 Text en Copyright © 2012 Darius Widera et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Widera, Darius Hauser, Stefan Kaltschmidt, Christian Kaltschmidt, Barbara Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells |
title | Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells |
title_full | Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells |
title_fullStr | Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells |
title_full_unstemmed | Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells |
title_short | Origin and Regenerative Potential of Vertebrate Mechanoreceptor-Associated Stem Cells |
title_sort | origin and regenerative potential of vertebrate mechanoreceptor-associated stem cells |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467754/ https://www.ncbi.nlm.nih.gov/pubmed/23082250 http://dx.doi.org/10.1155/2012/837626 |
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