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Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease

Primary abnormalities of the autonomic nervous system had been postulated as the pathogenic mechanisms of myocardial damage, in patients with Chagas disease. However, recent investigations indicate that these abnormalities are secondary and amenable to treatment with beta-adrenergic blockers. Moreov...

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Detalles Bibliográficos
Autores principales: Dávila, Diego F., Donis, Jose H., Arata de Bellabarba, Gabriela, Villarroel, Vanesa, Sanchez, Francisco, Berrueta, Lisbeth, Salmen, Siham, Das Neves, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467757/
https://www.ncbi.nlm.nih.gov/pubmed/23091486
http://dx.doi.org/10.1155/2012/980739
Descripción
Sumario:Primary abnormalities of the autonomic nervous system had been postulated as the pathogenic mechanisms of myocardial damage, in patients with Chagas disease. However, recent investigations indicate that these abnormalities are secondary and amenable to treatment with beta-adrenergic blockers. Moreover, muscarinic cardiac autoantibodies appear to enhance parasympathetic activity on the sinus node. Therefore, the purpose of this paper is to analyze how knowledge on Chagas' disease evolved from being initially considered as a primary cardioneuromyopathy to the current status of a congestive cardiomyopathy of parasitic origin.