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Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease

Primary abnormalities of the autonomic nervous system had been postulated as the pathogenic mechanisms of myocardial damage, in patients with Chagas disease. However, recent investigations indicate that these abnormalities are secondary and amenable to treatment with beta-adrenergic blockers. Moreov...

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Autores principales: Dávila, Diego F., Donis, Jose H., Arata de Bellabarba, Gabriela, Villarroel, Vanesa, Sanchez, Francisco, Berrueta, Lisbeth, Salmen, Siham, Das Neves, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467757/
https://www.ncbi.nlm.nih.gov/pubmed/23091486
http://dx.doi.org/10.1155/2012/980739
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author Dávila, Diego F.
Donis, Jose H.
Arata de Bellabarba, Gabriela
Villarroel, Vanesa
Sanchez, Francisco
Berrueta, Lisbeth
Salmen, Siham
Das Neves, Barbara
author_facet Dávila, Diego F.
Donis, Jose H.
Arata de Bellabarba, Gabriela
Villarroel, Vanesa
Sanchez, Francisco
Berrueta, Lisbeth
Salmen, Siham
Das Neves, Barbara
author_sort Dávila, Diego F.
collection PubMed
description Primary abnormalities of the autonomic nervous system had been postulated as the pathogenic mechanisms of myocardial damage, in patients with Chagas disease. However, recent investigations indicate that these abnormalities are secondary and amenable to treatment with beta-adrenergic blockers. Moreover, muscarinic cardiac autoantibodies appear to enhance parasympathetic activity on the sinus node. Therefore, the purpose of this paper is to analyze how knowledge on Chagas' disease evolved from being initially considered as a primary cardioneuromyopathy to the current status of a congestive cardiomyopathy of parasitic origin.
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spelling pubmed-34677572012-10-22 Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease Dávila, Diego F. Donis, Jose H. Arata de Bellabarba, Gabriela Villarroel, Vanesa Sanchez, Francisco Berrueta, Lisbeth Salmen, Siham Das Neves, Barbara Interdiscip Perspect Infect Dis Review Article Primary abnormalities of the autonomic nervous system had been postulated as the pathogenic mechanisms of myocardial damage, in patients with Chagas disease. However, recent investigations indicate that these abnormalities are secondary and amenable to treatment with beta-adrenergic blockers. Moreover, muscarinic cardiac autoantibodies appear to enhance parasympathetic activity on the sinus node. Therefore, the purpose of this paper is to analyze how knowledge on Chagas' disease evolved from being initially considered as a primary cardioneuromyopathy to the current status of a congestive cardiomyopathy of parasitic origin. Hindawi Publishing Corporation 2012 2012-10-02 /pmc/articles/PMC3467757/ /pubmed/23091486 http://dx.doi.org/10.1155/2012/980739 Text en Copyright © 2012 Diego F. Dávila et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Dávila, Diego F.
Donis, Jose H.
Arata de Bellabarba, Gabriela
Villarroel, Vanesa
Sanchez, Francisco
Berrueta, Lisbeth
Salmen, Siham
Das Neves, Barbara
Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease
title Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease
title_full Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease
title_fullStr Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease
title_full_unstemmed Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease
title_short Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease
title_sort cardiac autonomic control mechanisms in the pathogenesis of chagas' heart disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467757/
https://www.ncbi.nlm.nih.gov/pubmed/23091486
http://dx.doi.org/10.1155/2012/980739
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