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Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease
Primary abnormalities of the autonomic nervous system had been postulated as the pathogenic mechanisms of myocardial damage, in patients with Chagas disease. However, recent investigations indicate that these abnormalities are secondary and amenable to treatment with beta-adrenergic blockers. Moreov...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2012
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467757/ https://www.ncbi.nlm.nih.gov/pubmed/23091486 http://dx.doi.org/10.1155/2012/980739 |
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author | Dávila, Diego F. Donis, Jose H. Arata de Bellabarba, Gabriela Villarroel, Vanesa Sanchez, Francisco Berrueta, Lisbeth Salmen, Siham Das Neves, Barbara |
author_facet | Dávila, Diego F. Donis, Jose H. Arata de Bellabarba, Gabriela Villarroel, Vanesa Sanchez, Francisco Berrueta, Lisbeth Salmen, Siham Das Neves, Barbara |
author_sort | Dávila, Diego F. |
collection | PubMed |
description | Primary abnormalities of the autonomic nervous system had been postulated as the pathogenic mechanisms of myocardial damage, in patients with Chagas disease. However, recent investigations indicate that these abnormalities are secondary and amenable to treatment with beta-adrenergic blockers. Moreover, muscarinic cardiac autoantibodies appear to enhance parasympathetic activity on the sinus node. Therefore, the purpose of this paper is to analyze how knowledge on Chagas' disease evolved from being initially considered as a primary cardioneuromyopathy to the current status of a congestive cardiomyopathy of parasitic origin. |
format | Online Article Text |
id | pubmed-3467757 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2012 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-34677572012-10-22 Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease Dávila, Diego F. Donis, Jose H. Arata de Bellabarba, Gabriela Villarroel, Vanesa Sanchez, Francisco Berrueta, Lisbeth Salmen, Siham Das Neves, Barbara Interdiscip Perspect Infect Dis Review Article Primary abnormalities of the autonomic nervous system had been postulated as the pathogenic mechanisms of myocardial damage, in patients with Chagas disease. However, recent investigations indicate that these abnormalities are secondary and amenable to treatment with beta-adrenergic blockers. Moreover, muscarinic cardiac autoantibodies appear to enhance parasympathetic activity on the sinus node. Therefore, the purpose of this paper is to analyze how knowledge on Chagas' disease evolved from being initially considered as a primary cardioneuromyopathy to the current status of a congestive cardiomyopathy of parasitic origin. Hindawi Publishing Corporation 2012 2012-10-02 /pmc/articles/PMC3467757/ /pubmed/23091486 http://dx.doi.org/10.1155/2012/980739 Text en Copyright © 2012 Diego F. Dávila et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Dávila, Diego F. Donis, Jose H. Arata de Bellabarba, Gabriela Villarroel, Vanesa Sanchez, Francisco Berrueta, Lisbeth Salmen, Siham Das Neves, Barbara Cardiac Autonomic Control Mechanisms in the Pathogenesis of Chagas' Heart Disease |
title | Cardiac Autonomic Control Mechanisms in the Pathogenesis of
Chagas' Heart Disease |
title_full | Cardiac Autonomic Control Mechanisms in the Pathogenesis of
Chagas' Heart Disease |
title_fullStr | Cardiac Autonomic Control Mechanisms in the Pathogenesis of
Chagas' Heart Disease |
title_full_unstemmed | Cardiac Autonomic Control Mechanisms in the Pathogenesis of
Chagas' Heart Disease |
title_short | Cardiac Autonomic Control Mechanisms in the Pathogenesis of
Chagas' Heart Disease |
title_sort | cardiac autonomic control mechanisms in the pathogenesis of
chagas' heart disease |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467757/ https://www.ncbi.nlm.nih.gov/pubmed/23091486 http://dx.doi.org/10.1155/2012/980739 |
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