Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease

Behcet's disease (BD) is a multisystemic inflammatory disease and is characterized by recurrent attacks on eyes, brain, skin, and gut. There is evidence that skewed T-cell responses contributed to its pathophysiology in patients with BD. We found that heat shock proteins (HSPs) reactive T cells...

Descripción completa

Detalles Bibliográficos
Autores principales: Shimizu, Jun, Izumi, Tomoko, Suzuki, Noboru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2012
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467778/
https://www.ncbi.nlm.nih.gov/pubmed/23082245
http://dx.doi.org/10.1155/2012/105205
_version_ 1782245871939747840
author Shimizu, Jun
Izumi, Tomoko
Suzuki, Noboru
author_facet Shimizu, Jun
Izumi, Tomoko
Suzuki, Noboru
author_sort Shimizu, Jun
collection PubMed
description Behcet's disease (BD) is a multisystemic inflammatory disease and is characterized by recurrent attacks on eyes, brain, skin, and gut. There is evidence that skewed T-cell responses contributed to its pathophysiology in patients with BD. We found that heat shock proteins (HSPs) reactive T cells were prevalent in patients with BD. Here, we summarize current findings on HSP reactive T cells and their contribution to the pathogenesis in patients with BD.
format Online
Article
Text
id pubmed-3467778
institution National Center for Biotechnology Information
language English
publishDate 2012
publisher Hindawi Publishing Corporation
record_format MEDLINE/PubMed
spelling pubmed-34677782012-10-18 Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease Shimizu, Jun Izumi, Tomoko Suzuki, Noboru Autoimmune Dis Review Article Behcet's disease (BD) is a multisystemic inflammatory disease and is characterized by recurrent attacks on eyes, brain, skin, and gut. There is evidence that skewed T-cell responses contributed to its pathophysiology in patients with BD. We found that heat shock proteins (HSPs) reactive T cells were prevalent in patients with BD. Here, we summarize current findings on HSP reactive T cells and their contribution to the pathogenesis in patients with BD. Hindawi Publishing Corporation 2012 2012-10-02 /pmc/articles/PMC3467778/ /pubmed/23082245 http://dx.doi.org/10.1155/2012/105205 Text en Copyright © 2012 Jun Shimizu et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Shimizu, Jun
Izumi, Tomoko
Suzuki, Noboru
Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease
title Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease
title_full Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease
title_fullStr Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease
title_full_unstemmed Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease
title_short Aberrant Activation of Heat Shock Protein 60/65 Reactive T Cells in Patients with Behcet's Disease
title_sort aberrant activation of heat shock protein 60/65 reactive t cells in patients with behcet's disease
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467778/
https://www.ncbi.nlm.nih.gov/pubmed/23082245
http://dx.doi.org/10.1155/2012/105205
work_keys_str_mv AT shimizujun aberrantactivationofheatshockprotein6065reactivetcellsinpatientswithbehcetsdisease
AT izumitomoko aberrantactivationofheatshockprotein6065reactivetcellsinpatientswithbehcetsdisease
AT suzukinoboru aberrantactivationofheatshockprotein6065reactivetcellsinpatientswithbehcetsdisease

Ejemplares similares