Effect of different lipids and surfactants on formulation of solid lipid nanoparticles incorporating tamoxifen citrate

Tamoxifen Citrate (TC) is an estrogen receptor antagonist and drug of choice for hormone sensitive breast cancer. Solid Lipid Nanoparticles loaded with TC were prepared by High Shear Homogenization followed by Ultrasonication. The aim of the present work is to study the effect of four different Soli...

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Detalles Bibliográficos
Autores principales: Upadhyay, S. U., Patel, J. K., Patel, V. A., Saluja, A. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original/Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467804/
https://www.ncbi.nlm.nih.gov/pubmed/23066183
http://dx.doi.org/10.4103/0975-7406.94161
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author Upadhyay, S. U.
Patel, J. K.
Patel, V. A.
Saluja, A. K.
author_facet Upadhyay, S. U.
Patel, J. K.
Patel, V. A.
Saluja, A. K.
author_sort Upadhyay, S. U.
collection PubMed
description Tamoxifen Citrate (TC) is an estrogen receptor antagonist and drug of choice for hormone sensitive breast cancer. Solid Lipid Nanoparticles loaded with TC were prepared by High Shear Homogenization followed by Ultrasonication. The aim of the present work is to study the effect of four different Solid Lipids and three Surfactants on Formulation and Stability of SLN. They were characterized for Particle size, Polydispersity Index and Zeta Potential by Zetasizer Nano. SLN prepared by Solid Lipid Compritol 888 (Glyceryldibehenate) and Tween 80 (1%) showed desired Particle Size of 206.9 nm, PDI of 0.046 and Zeta Potential of 9.32 mV.
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spelling pubmed-34678042012-10-12 Effect of different lipids and surfactants on formulation of solid lipid nanoparticles incorporating tamoxifen citrate Upadhyay, S. U. Patel, J. K. Patel, V. A. Saluja, A. K. J Pharm Bioallied Sci Original/Brief Tamoxifen Citrate (TC) is an estrogen receptor antagonist and drug of choice for hormone sensitive breast cancer. Solid Lipid Nanoparticles loaded with TC were prepared by High Shear Homogenization followed by Ultrasonication. The aim of the present work is to study the effect of four different Solid Lipids and three Surfactants on Formulation and Stability of SLN. They were characterized for Particle size, Polydispersity Index and Zeta Potential by Zetasizer Nano. SLN prepared by Solid Lipid Compritol 888 (Glyceryldibehenate) and Tween 80 (1%) showed desired Particle Size of 206.9 nm, PDI of 0.046 and Zeta Potential of 9.32 mV. Medknow Publications & Media Pvt Ltd 2012-03 /pmc/articles/PMC3467804/ /pubmed/23066183 http://dx.doi.org/10.4103/0975-7406.94161 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original/Brief
Upadhyay, S. U.
Patel, J. K.
Patel, V. A.
Saluja, A. K.
Effect of different lipids and surfactants on formulation of solid lipid nanoparticles incorporating tamoxifen citrate
title Effect of different lipids and surfactants on formulation of solid lipid nanoparticles incorporating tamoxifen citrate
title_full Effect of different lipids and surfactants on formulation of solid lipid nanoparticles incorporating tamoxifen citrate
title_fullStr Effect of different lipids and surfactants on formulation of solid lipid nanoparticles incorporating tamoxifen citrate
title_full_unstemmed Effect of different lipids and surfactants on formulation of solid lipid nanoparticles incorporating tamoxifen citrate
title_short Effect of different lipids and surfactants on formulation of solid lipid nanoparticles incorporating tamoxifen citrate
title_sort effect of different lipids and surfactants on formulation of solid lipid nanoparticles incorporating tamoxifen citrate
topic Original/Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467804/
https://www.ncbi.nlm.nih.gov/pubmed/23066183
http://dx.doi.org/10.4103/0975-7406.94161
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