Design and development of colon specific microspheres for chronotherapy of hypertension

The purpose of this research was to design, and evaluate multiparticulate systems for Chronotherapeutic delivery of beta blocker containing biodegradable polymers coated with pH sensitive polymers in hypertension. Chitosan was used as a carrier for drug delivery and Eudragit S100 was used as an ente...

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Detalles Bibliográficos
Autores principales: Patel, P., Dhake, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original/Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467814/
https://www.ncbi.nlm.nih.gov/pubmed/23066197
http://dx.doi.org/10.4103/0975-7406.94132
Descripción
Sumario:The purpose of this research was to design, and evaluate multiparticulate systems for Chronotherapeutic delivery of beta blocker containing biodegradable polymers coated with pH sensitive polymers in hypertension. Chitosan was used as a carrier for drug delivery and Eudragit S100 was used as an enteric coating polymer. 3(2) full factorial design was employed to optimize the proper formulation for Chronotherapeutic drug delivery.

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