Design and characterization of controlled release gastro-retentive floating tablet of an atypical psychotropic agent

The purpose of the present work was to design and evaluate the once daily sustained release matrix type gastro-retentive floating tablet of Quetiapine Fumarate base on hydrophilic matrices of HPMC, sodium CMC and Carbopol. Sodium bicarbonate was incorporated as a gas-generating agent to give buoyanc...

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Detalles Bibliográficos
Autores principales: Ukawala, Ravikumar, Singhvi, Gautam, Jain, Suresh, Shukla, Vipin, Yadav, Nilesh, Sharma, Sohiny
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2012
Materias:
Original/Brief
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467820/
https://www.ncbi.nlm.nih.gov/pubmed/23066221
http://dx.doi.org/10.4103/0975-7406.94151
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author Ukawala, Ravikumar
Singhvi, Gautam
Jain, Suresh
Shukla, Vipin
Yadav, Nilesh
Sharma, Sohiny
author_facet Ukawala, Ravikumar
Singhvi, Gautam
Jain, Suresh
Shukla, Vipin
Yadav, Nilesh
Sharma, Sohiny
author_sort Ukawala, Ravikumar
collection PubMed
description The purpose of the present work was to design and evaluate the once daily sustained release matrix type gastro-retentive floating tablet of Quetiapine Fumarate base on hydrophilic matrices of HPMC, sodium CMC and Carbopol. Sodium bicarbonate was incorporated as a gas-generating agent to give buoyancy. In-vitro drug release studies were performed in pH 1.2 buffer using USP type II paddle at 50 rpm. The release rate of drug decreased with increasing polymer proportion of HPMC K15M from 20 to 60 mg. Formulation with desired drug release achieved with combination of sodium CMC and K15M in ratio of 1:3. The drug release mechanism was predominantly found to be Non-Fickian diffusion and Higuchi controlled.
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spelling pubmed-34678202012-10-12 Design and characterization of controlled release gastro-retentive floating tablet of an atypical psychotropic agent Ukawala, Ravikumar Singhvi, Gautam Jain, Suresh Shukla, Vipin Yadav, Nilesh Sharma, Sohiny J Pharm Bioallied Sci Original/Brief The purpose of the present work was to design and evaluate the once daily sustained release matrix type gastro-retentive floating tablet of Quetiapine Fumarate base on hydrophilic matrices of HPMC, sodium CMC and Carbopol. Sodium bicarbonate was incorporated as a gas-generating agent to give buoyancy. In-vitro drug release studies were performed in pH 1.2 buffer using USP type II paddle at 50 rpm. The release rate of drug decreased with increasing polymer proportion of HPMC K15M from 20 to 60 mg. Formulation with desired drug release achieved with combination of sodium CMC and K15M in ratio of 1:3. The drug release mechanism was predominantly found to be Non-Fickian diffusion and Higuchi controlled. Medknow Publications & Media Pvt Ltd 2012-03 /pmc/articles/PMC3467820/ /pubmed/23066221 http://dx.doi.org/10.4103/0975-7406.94151 Text en Copyright: © Journal of Pharmacy and Bioallied Sciences http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original/Brief
Ukawala, Ravikumar
Singhvi, Gautam
Jain, Suresh
Shukla, Vipin
Yadav, Nilesh
Sharma, Sohiny
Design and characterization of controlled release gastro-retentive floating tablet of an atypical psychotropic agent
title Design and characterization of controlled release gastro-retentive floating tablet of an atypical psychotropic agent
title_full Design and characterization of controlled release gastro-retentive floating tablet of an atypical psychotropic agent
title_fullStr Design and characterization of controlled release gastro-retentive floating tablet of an atypical psychotropic agent
title_full_unstemmed Design and characterization of controlled release gastro-retentive floating tablet of an atypical psychotropic agent
title_short Design and characterization of controlled release gastro-retentive floating tablet of an atypical psychotropic agent
title_sort design and characterization of controlled release gastro-retentive floating tablet of an atypical psychotropic agent
topic Original/Brief
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3467820/
https://www.ncbi.nlm.nih.gov/pubmed/23066221
http://dx.doi.org/10.4103/0975-7406.94151
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